The causal association between ischemic stroke and the risk of membranous nephropathy based on two-sample Mendelian randomization

LIU Yimin; ZHANG Li′e; PENG Yang; LI Zhenning; ZOU Yunfeng

doi:10.16462/j.cnki.zhjbkz.2024.05.011

Volume 28 Issue 5

May 2024

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LIU Yimin, ZHANG Li′e, PENG Yang, LI Zhenning, ZOU Yunfeng. The causal association between ischemic stroke and the risk of membranous nephropathy based on two-sample Mendelian randomization[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 561-565. doi: 10.16462/j.cnki.zhjbkz.2024.05.011

Citation:

LIU Yimin, ZHANG Li′e, PENG Yang, LI Zhenning, ZOU Yunfeng. The causal association between ischemic stroke and the risk of membranous nephropathy based on two-sample Mendelian randomization[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 561-565. doi: 10.16462/j.cnki.zhjbkz.2024.05.011

Citation:

LIU Yimin, ZHANG Li′e, PENG Yang, LI Zhenning, ZOU Yunfeng. The causal association between ischemic stroke and the risk of membranous nephropathy based on two-sample Mendelian randomization[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 561-565. doi: 10.16462/j.cnki.zhjbkz.2024.05.011

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The causal association between ischemic stroke and the risk of membranous nephropathy based on two-sample Mendelian randomization

doi: 10.16462/j.cnki.zhjbkz.2024.05.011

LIU Yimin^{1, 2, 3},
ZHANG Li′e^{2, 3, 4},
PENG Yang^{2, 3, 4},
LI Zhenning^{1, 3},
ZOU Yunfeng^{1, 2, 3
,
,}

1.
Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China
2.
Guangxi Key Laboratory of Environment and Health, Guangxi Medical University, Nanning 530021, China
3.
Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China
4.
Department of Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China

Funds:

National Natural Science Foundation of China 82003410

National Natural Science Foundation of China 42367063

Natural Science Foundation of Guangxi Province 2019GXNSFGA245002

Natural Science Foundation of Guangxi Province 2023GXNSFBA026109

More Information

Corresponding author: ZOU Yunfeng, E-mail: zouyunfeng@gxmu.edu.cn
Received Date: 2023-11-09
Rev Recd Date: 2024-03-16

Available Online: 2024-06-05

Publish Date: 2024-05-10

Abstract

Abstract

Objective To investigate the causal relationship between ischemic stroke and incidence of membranous nephropathy using a Two-sample Mendelian randomization (MR) method. Methods Single nucleotide polymorphisms (SNPs), which were independent of each other and closely associated with ischemic stroke were identified from a Genome-Wide Association analysis. The identified SNPs were used as instrumental variables. Odds ratios were obtained from the MR analyses on the causal association between ischemic stroke and membranous nephropathy using the inverse variance weighted analysis, weighted median method, and MR-Egger method. Results A total of 17 SNPs that were associated with ischemic stroke were identified in this study. The inverse variance weighted analysis showed that ischemic stroke was associated with higher risk of membranous nephropathy (OR=1.61, 95% CI: 1.11-2.33, P=0.01). Results of the sensitivity analysis were consistent with those of the main analysis, confirming the robustness of this study. No heterogeneity among SNPs was observed in this study. Conclusions From a genetic perspective, the present study suggested an association between ischaemic stroke and elevated risk of membranous nephropathy. Strengthening screening and prevention of membranous nephropathy among patients diagnosed with ischemic stroke is of great clinical and public health significance.
- Ischemic stroke,
- Membranous nephropathy,
- Mendelian randomization,
- Causal inference

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References(24)

References

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