Study on the relationship between insulin resistance and cardiovascular disease risk based on a coal mining population in Northern Shaanxi

DU Yuanzhen; Tao Xinrong; ZOU Yuanjie; DING Yu; MU Min; CHEN Qianwei

doi:10.16462/j.cnki.zhjbkz.2024.05.012

Volume 28 Issue 5

May 2024

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DU Yuanzhen, Tao Xinrong, ZOU Yuanjie, DING Yu, MU Min, CHEN Qianwei. Study on the relationship between insulin resistance and cardiovascular disease risk based on a coal mining population in Northern Shaanxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 566-573. doi: 10.16462/j.cnki.zhjbkz.2024.05.012

Citation:

DU Yuanzhen, Tao Xinrong, ZOU Yuanjie, DING Yu, MU Min, CHEN Qianwei. Study on the relationship between insulin resistance and cardiovascular disease risk based on a coal mining population in Northern Shaanxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 566-573. doi: 10.16462/j.cnki.zhjbkz.2024.05.012

Citation:

DU Yuanzhen, Tao Xinrong, ZOU Yuanjie, DING Yu, MU Min, CHEN Qianwei. Study on the relationship between insulin resistance and cardiovascular disease risk based on a coal mining population in Northern Shaanxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 566-573. doi: 10.16462/j.cnki.zhjbkz.2024.05.012

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Study on the relationship between insulin resistance and cardiovascular disease risk based on a coal mining population in Northern Shaanxi

doi: 10.16462/j.cnki.zhjbkz.2024.05.012

Joint Research Center for Occupational Medicine and Health of Institute of Health and Medicine, Hefei Comprehensive National Science Center, Anhui University of Science and Technology, Huainan 232000, China

Funds:

Joint Research Center for Occupational Medicine and Health of IHM, Anhui University of Science and Technology, Huainan, 232000, Supported by Research Funds of Joint Research Center for Occupational Medicine and Health of IHM) OMH-2023-20

The Open Research Grant of the Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining EC2021008

The Collaborative Innovation Project of Colleges and Universities of Anhui Province GXXT-2022-065

More Information

Corresponding author: MU Min, E-mail: candymu@126.com; CHEN Qianwei, E-mail: 1026641788@qq.com
Received Date: 2024-01-16
Rev Recd Date: 2024-03-28

Available Online: 2024-06-05

Publish Date: 2024-05-10

Abstract

Abstract

Objective To investigate the relationship between insulin resistance (IR) and cardiovascular disease (CVD) risk in a population of miners. Methods The data were collected from a cross-sectional study of a group of coal miners in Northern Shaanxi Province between 2020 and 2023. TyG/TyG-BMI was developed to indicate insulin resistance in the body based on TG and FPG levels, while the Prediction for ASCVD Risk (PAR) was created to assess the risk of cardiovascular disease using factors including sex, age, waist circumference, blood pressure, cholesterol levels, smoking habits, medical history, and geographic location. BMI group: underweight group with BMI < 18.5 kg/m², normal group with BMI ≤ 24.0 kg/m², overweight group with BMI < 28.0 kg/m² and obesity group with BMI≥28.0 kg/m². The TyG and TyG-BMI variables were divided into three groups (T₁, T₂, and T₃) according to their tertiles, with the T₁ group serving as the reference group. To explore the association between insulin resistance and the risk of cardiovascular disease, a logistic regression model was employed. Results Totally 4 359 subjects were included. After adjusting for covariates, each unit increases in the TyG increased high PAR by 27.6%(OR=1.276, 95% CI: 1.193-1.365).The high PAR in the group with the TyG in T₃ was 3.013 times of that in the group T₁ (OR=3.013, 95% CI: 2.341-3.879). Sensitivity analysis and the subgroup analysis confirmed the stability of the association between the TyG and the PAR. In the general population, for every unit increase in the TyG as a continuous variable, the high PAR increased by 29.1%(OR=1.291, 95% CI: 1.171-1.422). As a categorical variable, the risk for high PAR in the T₃ group was 3.658 times of that in the T₁ group (OR=3.658, 95% CI: 2.550-5.247). In the hyperreconstituted population, for every unit increase in the TyG as a continuous variable, the risk for high PAR increase by 56.9% (OR=1.569, 95% CI: 1.402-1.756). As a categorical variable, the risk for high PAR in the T₃ group was 5.610 times of that in the T₁ group (OR=5.610, 95% CI: 3.753-8.386). In the obese population, for every unit increased in the TyG as a continuous variable, the high PAR increased by 47.5% (OR=1.475, 95% CI: 1.211-1.796). As a categorical variable, the risk for high PAR in the T₃ group was 4.147 times of that in the T₁ group (OR=4.147, 95% CI: 2.254-7.628). No statistically significant association existed between TyG and PAR in individuals with the obese population. Conclusions In coal mining populations, elevated levels of body insulin resistance strongly associates with an increased risk of developing cardiovascular disease. BMI may modulate this relationship. Early suppression of elevated levels of body insulin resistance, before the onset of overweight or obesity, may positively influence the prevention and control of atherosclerotic cardiovascular disease.
- Coal miners,
- Triglyceride-glucose index,
- Insulin resistance,
- Obesity

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References(16)

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