Research progress on the impact of COVID-19 infection during pregnancy on the health outcomes of pregnant women and their offspring

QIN Chenyuan; LIU Min; LIU Jue

doi:10.16462/j.cnki.zhjbkz.2024.05.014

Volume 28 Issue 5

May 2024

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2024 > 28(5): 581-585

QIN Chenyuan, LIU Min, LIU Jue. Research progress on the impact of COVID-19 infection during pregnancy on the health outcomes of pregnant women and their offspring[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 581-585. doi: 10.16462/j.cnki.zhjbkz.2024.05.014

Citation:

QIN Chenyuan, LIU Min, LIU Jue. Research progress on the impact of COVID-19 infection during pregnancy on the health outcomes of pregnant women and their offspring[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 581-585. doi: 10.16462/j.cnki.zhjbkz.2024.05.014

Citation:

PDF( 814 KB)

Research progress on the impact of COVID-19 infection during pregnancy on the health outcomes of pregnant women and their offspring

doi: 10.16462/j.cnki.zhjbkz.2024.05.014

QIN Chenyuan^{1, 2},
LIU Min¹,
LIU Jue^{1, 2
,
,}

1.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
2.
Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China

Funds:

Natural Science Foundation of Beijing L222027

Science Foundation of Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health 20230315

More Information

Corresponding author: LIU Jue, E-mail: jueliu@bjmu.edu.cn
Received Date: 2023-08-10
Rev Recd Date: 2023-10-21

Available Online: 2024-06-05

Publish Date: 2024-05-10

Abstract

Abstract

The impact of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection during pregnancy on the health outcomes of both mothers and offspring has been a major focus of international research during the COVID-19 pandemic. Pregnant women have long been recognized as a vulnerable group during infectious disease epidemics due to physiological changes in their immune, cardiovascular, and respiratory systems. Increasing evidence suggested that SARS-CoV-2 infection during pregnancy is associated with several adverse maternal outcomes, including complications during pregnancy, premature delivery, hospitalization or admission to the intensive care unit, and even death. Additionally, adverse outcomes for offspring include premature birth, stillbirth, low birth weight, being small for gestational age, and long-term neurobehavioral developmental abnormalities. This article reviews the adverse effects of SARS-CoV-2 infection during pregnancy on the short- and long-term health outcomes of pregnant women and their offspring. The aim is to provide scientific evidence for counseling on pregnancy risks related to COVID-19, as well as for obstetric and neonatal care.
- SARS-CoV-2,
- COVID-19,
- Maternal and child health,
- Research progress

FullText(HTML)

References(28)

References

[1]	WHO. COVID-19 dashboard[EB/OL]. (2023-10-14)[2023-10-16]. https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
[2]	Kumar D, Verma S, Mysorekar IU. COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy[J]. Transl Res, 2023, 251: 84-95. DOI: 10.1016/j.trsl.2022.08.007.
[3]	Smith ER, Oakley E, Grandner GW, et al. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis[J]. BMJ Glob Health, 2023, 8(1): e009495. DOI: 10.1136/bmjgh-2022-009495.
[4]	Ahlberg M, Neovius M, Saltvedt S, et al. Association of SARS-CoV-2 test status and pregnancy outcomes[J]. JAMA, 2020, 324(17): 1782-1785. DOI: 10.1001/jama.2020.19124.
[5]	Jering KS, Claggett BL, Cunningham JW, et al. Clinical characteristics and outcomes of hospitalized women giving birth with and without COVID-19[J]. JAMA Intern Med, 2021, 181(5): 714-717. DOI: 10.1001/jamainternmed.2020.9241.
[6]	Darling AM, Shephard H, Nestoridi E, et al. SARS-CoV-2 infection during pregnancy and preterm birth in Massachusetts from March 2020 through March 2021[J]. Paediatr Perinat Epidemiol, 2023, 37(2): 93-103. DOI: 10.1111/ppe.12944.
[7]	Karasek D, Baer RJ, McLemore MR, et al. The association of COVID-19 infection in pregnancy with preterm birth: a retrospective cohort study in California[J]. Lancet Reg Health Am, 2021, 2: 100027. DOI: 10.1016/j.lana.2021.100027.
[8]	Khalil A, von Dadelszen P, Draycott T, et al. Change in the incidence of stillbirth and preterm delivery during the COVID-19 pandemic[J]. JAMA, 2020, 324(7): 705-706. DOI: 10.1001/jama.2020.12746.
[9]	DeSisto CL, Wallace B, Simeone RM, et al. Risk for stillbirth among women with and without COVID-19 at delivery hospitalization - United States, March 2020-September 2021[J]. MMWR Morbid Mortal, 2021, 70(47): 1640-1645. DOI: 10.15585/mmwr.mm7047e1.
[10]	Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis[J]. BMJ, 2020, 370: m3320. DOI: 10.1136/bmj.m3320.
[11]	Metz TD, Clifton RG, Hughes BL, et al. Association of SARS-CoV-2 infection with serious maternal morbidity and mortality from obstetric complications[J]. JAMA, 2022, 327(8): 748-759. DOI: 10.1001/jama.2022.1190.
[12]	Emeruwa UN, Ona S, Shaman JL, et al. Associations between built environment, neighborhood socioeconomic status, and SARS-CoV-2 infection among pregnant women in New York city[J]. JAMA, 2020, 324(4): 390-392. DOI: 10.1001/jama.2020.11370.
[13]	Villar J, Ariff S, Gunier RB, et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study[J]. JAMA Pediatr, 2021, 175(8): 817-826. DOI: 10.1001/jamapediatrics.2021.1050.
[14]	Jardine J, Morris E. COVID-19 in women's health: epidemiology[J]. Best Pract Res Clin Obstet Gynaecol, 2021, 73: 81-90. DOI: 10.1016/j.bpobgyn.2021.03.010.
[15]	Nachega JB, Sam-Agudu NA, Machekano RN, et al. Severe acute respiratory syndrome coronavirus 2 infection and pregnancy in sub-saharan Africa: a 6-country retrospective cohort analysis[J]. Clin Infect Dis, 2022, 75(11): 1950-1961. DOI: 10.1093/cid/ciac294.
[16]	Aabakke AJM, Petersen TG, Wøjdemann K, et al. Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: a nationwide cohort study with validation of the SARS-CoV-2 diagnosis[J]. Acta Obstet Gynecol Scand, 2023, 102(3): 282-293. DOI: 10.1111/aogs.14512.
[17]	Zhang JL, Yuan HL, Xu LP, et al. The impact of COVID-19 on the mental health of pregnant women in Shanghai, China[J]. Front Public Health, 2022, 10: 938156. DOI: 10.3389/fpubh.2022.938156.
[18]	Guo JM, Li X, He JL, et al. A propensity score matching study: the prevalence of mental health problems among pregnant women at first antenatal care increased in Chongqing during the first wave of the COVID-19 pandemic[J]. Front Public Health, 2023, 11: 1142461. DOI: 10.3389/fpubh.2023.1142461.
[19]	Narang K, Enninga EAL, Gunaratne MDSK, et al. SARS-CoV-2 infection and COVID-19 during pregnancy: a multidisciplinary review[J]. Mayo Clin Proc, 2020, 95(8): 1750-1765. DOI: 10.1016/j.mayocp.2020.05.011.
[20]	Pinheiro GSMA, de Souza RC, de Oliveira Azevedo VMG, et al. Effects of intrauterine exposure to SARS-CoV-2 on infants' development: a rapid review and meta-analysis[J]. Eur J Pediatr, 2023, 182(5): 2041-2055. DOI: 10.1007/s00431-023-04910-8.
[21]	Hessami K, Norooznezhad AH, Monteiro S, et al. COVID-19 pandemic and infant neurodevelopmental impairment: a systematic review and meta-analysis[J]. JAMA Netw Open, 2022, 5(10): e2238941. DOI: 10.1001/jamanetworkopen.2022.38941.
[22]	Allotey J, Chatterjee S, Kew T, et al. SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis[J]. BMJ, 2022, 376: e067696. DOI: 10.1136/bmj-2021-067696.
[23]	Chen HJ, Guo JJ, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records[J]. Lancet, 2020, 395(10226): 809-815. DOI: 10.1016/S0140-6736(20)30360-3.
[24]	Villar J, Soto Conti CP, Gunier RB, et al. Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study[J]. Lancet, 2023, 401(10375): 447-457. DOI: 10.1016/S0140-6736(22)02467-9.
[25]	Smith ER, Oakley E, Grandner GW, et al. Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis[J]. Am J Obstet Gynecol, 2023, 228(2): 161-177. DOI: 10.1016/j.ajog.2022.08.038.
[26]	Molloy EJ, Nakra N, Gale C, et al. Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management[J]. Pediatr Res, 2023, 93(6): 1499-1508. DOI: 10.1038/s41390-022-02263-w.
[27]	Morhart P, Mardin C, Rauh M, et al. Maternal SARS-CoV-2 infection during pregnancy: possible impact on the infant[J]. Eur J Pediatr, 2022, 181(1): 413-418. DOI: 10.1007/s00431-021-04221-w.
[28]	Jiang Y, Yu X, Deng MG, et al. Maternal SARS-CoV-2 infection and aplasia cutis congenita in a newborn[J]. J Eur Acad Dermatol Venereol, 2022, 36(11): e868-e870. DOI: 10.1111/jdv.18343.