Application of microfluidic chips in the study of pneumoconiosis

TIAN Chang; SHAO Chaojie; LI Mengxue; ZHOU Lin; HUANG Hui; CHU Fengjen; MU Min; YE Dongqing

doi:10.16462/j.cnki.zhjbkz.2024.05.016

Volume 28 Issue 5

May 2024

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2024 > 28(5): 591-595

TIAN Chang, SHAO Chaojie, LI Mengxue, ZHOU Lin, HUANG Hui, CHU Fengjen, MU Min, YE Dongqing. Application of microfluidic chips in the study of pneumoconiosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 591-595. doi: 10.16462/j.cnki.zhjbkz.2024.05.016

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TIAN Chang, SHAO Chaojie, LI Mengxue, ZHOU Lin, HUANG Hui, CHU Fengjen, MU Min, YE Dongqing. Application of microfluidic chips in the study of pneumoconiosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 591-595. doi: 10.16462/j.cnki.zhjbkz.2024.05.016

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Application of microfluidic chips in the study of pneumoconiosis

doi: 10.16462/j.cnki.zhjbkz.2024.05.016

TIAN Chang^{1, 2
,
,},
SHAO Chaojie³,
LI Mengxue³,
ZHOU Lin³,
HUANG Hui³,
CHU Fengjen^{1, 2},
MU Min^{1, 2},
YE Dongqing^{1, 2
,
,}

1.
Department of Preventive Medicine, School of Public Health, Anhui University of Science and Technology, Huainan 232001, China
2.
Key Laboratory of Industrial Dust Prevention and Control, Occupational Safety and Health, Ministry of Education, Anhui University of Science and Technology, Huainan 232001, China
3.
School of Medicine, Anhui University of Science and Technology, Huainan 232001, China

Funds:

Anhui Provincial Natural Science Foundation 2108085QH358

Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology 13200387

Natural Science Research Project of Anhui Educational Committee 2022AH050829

University-level Key Projects of Anhui University of Science and Technology xjzd2020-20

More Information

Corresponding author: TIAN Chang, E-mail: tianchang984@163.com; YE Dongqing, E-mail: ydqph@aust.edu.cn
Received Date: 2023-06-28
Rev Recd Date: 2023-11-29

Available Online: 2024-06-05

Publish Date: 2024-05-10

Abstract

Abstract

Pneumoconiosis is a serious occupational disease that threats human health in physical and mental. Studying its mechanism is of great significance in the prevention, diagnosis, and treatment of pneumoconiosis. However, there are many technical difficulties in the traditional in-vivo and in-vitro research methods, which are unable to reproduce the three-dimensional lung tissue and the physical and biological microenvironment of the lung in-vivo, and it is difficult to conduct real-time dynamic observation of the physiological and biochemical processes, which restricts the research on the pathological mechanism of pneumoconiosis. Microfluidic chips, with their ability to manipulate cells, particles and solutions in time and space, provide new ideas for simulating the state of the lungs and reconstructing their physical and biological microenvironment. Starting from the interaction between dust particles and the lungs, this article reviews the deposition characteristics of dust particles in the lungs, the physiological and biochemical changes caused by dust particles on the lungs, and the research progress in the interaction between dust particles and pneumoconiosis using microfluidic chips.
- Microfluidics,
- Occupational Diseases,
- Pneumoconiosis,
- Organ-on-a-chip

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References(31)

References

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