HE Fenglan, YI Liu, Gan Xia, TU Junling, HUANG Siping, LI Mei, QIAN Ke, XIA Wen, NI Xiansheng. Epidemiological characteristics and etiological analysis of norovirus gastroenteritis outbreaks among children in Nanchang from 2016 to 2023[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(6): 740-744. doi: 10.16462/j.cnki.zhjbkz.2024.06.019
Citation:
HE Fenglan, YI Liu, Gan Xia, TU Junling, HUANG Siping, LI Mei, QIAN Ke, XIA Wen, NI Xiansheng. Epidemiological characteristics and etiological analysis of norovirus gastroenteritis outbreaks among children in Nanchang from 2016 to 2023[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(6): 740-744. doi: 10.16462/j.cnki.zhjbkz.2024.06.019
HE Fenglan, YI Liu, Gan Xia, TU Junling, HUANG Siping, LI Mei, QIAN Ke, XIA Wen, NI Xiansheng. Epidemiological characteristics and etiological analysis of norovirus gastroenteritis outbreaks among children in Nanchang from 2016 to 2023[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(6): 740-744. doi: 10.16462/j.cnki.zhjbkz.2024.06.019
Citation:
HE Fenglan, YI Liu, Gan Xia, TU Junling, HUANG Siping, LI Mei, QIAN Ke, XIA Wen, NI Xiansheng. Epidemiological characteristics and etiological analysis of norovirus gastroenteritis outbreaks among children in Nanchang from 2016 to 2023[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(6): 740-744. doi: 10.16462/j.cnki.zhjbkz.2024.06.019
Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Center for Disease Control and Prevention, Nanchang 330038, China
2.
Department of Infectious Diseases, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
3.
Nanchang Donghu District Center for Disease Control and Prevention, Nanchang 330006, China
HE Fenglan and YI Liu contributed equally to this article
Funds:
Science and Technology Department of Jiangxi Province20202BBGL73053
Science and Technology Bureau of Nanchang City2020-133-17
Objective To analyze the epidemiological characteristics and genetic diversity of norovirus gastroenteritis outbreaks among children in Nanchang from March 2016 to February 2023, and to provide scientific basis for the prevention and control of viral gastroenteritis in children.Methods The epidemiological characteristics of norovirus gastroenteritis outbreaks in children were analyzed in Nanchang City from March 2016 to February 2023. Anal swab samples and/or vomits were collected. real-time fluorescence quantitative polymerase chain reaction (RT-PCR) was used to identify norovirus GI and GII genogroups. Specific primers were used to amplify the nucleic acid among positive samples. The amplified products were sequenced and analyzed for genotype and recombination.Results A total of 89 outbreaks of norovirus gastroenteritis in children were investigated during 7 years, including 49 outbreaks in kindergartens and 40 outbreaks in primary schools. The average number of cases involved in each outbreak was 14.71, and the total attack rate was 3.18 %. The sex ratio was 1.22∶1.00 (male/female), and the average epidemic time was about 3 days. The high incidence month was from October to February of the following year of the total epidemic. Urban childcare institutions were places with high incidence of epidemic. A total of 823 samples were collected, and the positive rate of norovirus nucleic acid was 55.65%. There were 6 outbreaks of GI norovirus, 81 outbreaks of GII norovirus, and 2 outbreaks of co-infection. Among them, 73 outbreaks were sequenced successfully, and 14 genotypes were identified. The GI norovirus was GⅠ.3[P13], GⅠ.6[P11]P, GⅠ.4[P4]. GII norovirus was dominated by GⅡ.2, GⅡ.6 and GⅡ.7 subtypes, with 11 genotypes. GⅡ.2 [P16] accounted for the highest proportion, and the dominant genotype changed from GⅡ.2 to other types.Conclusions In recent years, the epidemic of norovirus gastroenteritis in children was mainly concentrated in urban kindergartens, and winter was the high incidence season in Nanchang. The main pathogen was GII norovirus, with multiple gene recombination types mainly GⅡ.2 [P16] circulating at the same time.
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