Multiple trace elements co-exposure and risk of preterm birth

WANG Ying; WU Weiwei; ZHANG Ping; GUO Hui; LIU Sijia; CHEN Xi; FENG Yongliang; YANG Hailan; WANG Suping; ZHANG Yawei

doi:10.16462/j.cnki.zhjbkz.2025.06.006

Volume 29 Issue 6

Jun. 2025

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2025 > 29(6): 662-668

WANG Ying, WU Weiwei, ZHANG Ping, GUO Hui, LIU Sijia, CHEN Xi, FENG Yongliang, YANG Hailan, WANG Suping, ZHANG Yawei. Multiple trace elements co-exposure and risk of preterm birth[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 662-668. doi: 10.16462/j.cnki.zhjbkz.2025.06.006

Citation:

WANG Ying, WU Weiwei, ZHANG Ping, GUO Hui, LIU Sijia, CHEN Xi, FENG Yongliang, YANG Hailan, WANG Suping, ZHANG Yawei. Multiple trace elements co-exposure and risk of preterm birth[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 662-668. doi: 10.16462/j.cnki.zhjbkz.2025.06.006

Citation:

WANG Ying, WU Weiwei, ZHANG Ping, GUO Hui, LIU Sijia, CHEN Xi, FENG Yongliang, YANG Hailan, WANG Suping, ZHANG Yawei. Multiple trace elements co-exposure and risk of preterm birth[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 662-668. doi: 10.16462/j.cnki.zhjbkz.2025.06.006

PDF( 0 KB)

Multiple trace elements co-exposure and risk of preterm birth

doi: 10.16462/j.cnki.zhjbkz.2025.06.006

WANG Ying^{1, 2},
WU Weiwei^{1, 2},
ZHANG Ping¹,
GUO Hui¹,
LIU Sijia¹,
CHEN Xi³,
FENG Yongliang^{1, 2},
YANG Hailan⁴,
WANG Suping^{1, 2
,
,},
ZHANG Yawei^{5
,
,}

1.
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China
2.
Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China
3.
National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100000, China
4.
Obstetrics and Gynecology, First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China
5.
Department of Cancer Prevention and Control, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100000, China

Funds:

National Natural Science Foundation of China 82204145

National Natural Science Foundation of China 82373677

Natural Science Basic Research Program of Shanxi Province 20210302124583

Central Government Guides Local Science and Technology Development Fund Project YDZX20201400001058

Doctoral Initiation Fund of Shanxi Medical University XD2023

Shanxi Province Higher Education " Billion Prigect" Science and Techonology Guidance Project 2024

More Information

Corresponding author: WANG Suping, E-mail: supingwang@sxmu.edu.cn; ZHANG Yawei, E-mail: zhangya69@foxmail.com
Received Date: 2024-12-19
Rev Recd Date: 2025-03-11
Publish Date: 2025-06-10

Abstract

Abstract

Objective To examine the association between trace elements co-exposure and risk of preterm birth. Methods A total of 1 922 mother infant pairs who joined a birth cohort in taiyuan from 2012 to 2016 were selected as the study population. The concentrations of Vanadium (V), Chromium (Cr), Manganese (Mn), Cobalt (Co), Nickel (Ni), Copper (Cu), Zinc (Zn), Selenium (Se), and Molybdenum (Mo) in maternal and umbilical cord blood were determined using inductively coupled plasma mass spectrometry (ICP-MS). We employed quartile g-computation (QGCOMP) to examine trace elements co-exposure in relation to preterm birth. Results An increased risk of preterm birth was associated with maternal Cu (OR=1.58, 95% CI: 1.01-2.49). High maternal exposure level of Se was associated with preterm birth (OR=0.50, 95% CI: 0.26-0.96). An increased risk of preterm birth was associated with cord blood Mn (OR=1.70, 95% CI: 1.04-2.78). Both medium (OR=0.41, 95% CI: 0.26-0.66) and high (OR=0.54, 95% CI: 0.33-0.88) cord blood level of Zn was associated with preterm birth. The QGCOMP showed that preterm birth was associated with maternal metal co-exposure (-0.53, 95% CI: -0.86--0.19) and cord metal co-exposure (-0.47, 95% CI: -0.84--0.09). Cr contributed the most to the reduction in preterm birth in maternal trace elements co-exposure and Zn contributed the most in cord trace elements co-exposure. Conclusions Our study suggested that trace elements are associated with preterm birth, and the decreasing risk is driven by Zn, Se and Cr.
- Trace elements,
- Co-exposure,
- Preterm birth

FullText(HTML)

References(15)

References

[1]	Qiao J, Wang YY, Li XH, et al. A Lancet Commission on 70 years of women′s reproductive, maternal, newborn, child, and adolescent health in China [J]. Lancet, 2021, 397(10293): 2497-2536. doi: 10.1016/S0140-6736(20)32708-2.
[2]	Zhang WX, Chen H, Xia W, et al. Associations of plasma manganese with adverse pregnancy outcomes: nested case-control studies in a Chinese birth cohort [J]. Chemosphere, 2023, 345: 140550. doi: 10.1016/j.chemosphere.2023.140550.
[3]	Hao YX, Yan LL, Pang YM, et al. Maternal serum level of manganese, single nucleotide polymorphisms, and risk of spontaneous preterm birth: a nested case－control study in China[J]. Environ Pollut, 2020,262:114187. DOI: 10.1016/j.envpol.2020.114187.
[4]	Issah I, Duah MS, Arko-Mensah J, et al. Exposure to metal mixtures and adverse pregnancy and birth outcomes: a systematic review [J]. Sci Total Environ, 2024, 908: 168380. doi: 10.1016/j.scitotenv.2023.168380.
[5]	Gohari H, Khajavian N, Mahmoudian A, et al. Copper and zinc deficiency to the risk of preterm labor in pregnant women: a case-control study [J]. BMC Pregnancy Childbirth, 2023, 23(1): 366. doi: 10.1186/s12884-023-05625-2.
[6]	Ashrap P, Watkins DJ, Mukherjee B, et al. Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting [J]. Environ Res, 2021, 200: 111435. doi: 10.1016/j.envres.2021.111435.
[7]	Kumari D, Garg S, Bhawrani P. Zinc homeostasis in immunity and its association with preterm births [J]. Scand J Immunol, 2022, 95(4): e13142. doi: 10.1111/sji.13142.
[8]	Barman M, Brantsæter AL, Nilsson S, et al. Maternal dietary selenium intake is associated with increased gestational length and decreased risk of preterm delivery [J]. Br J Nutr, 2020, 123(2): 209-219. doi: 10.1017/S0007114519002113.
[9]	McDougall AR, Dore G, Aboud L, et al. The effect of selenium supplementation in pregnant women on maternal, fetal, and newborn outcomes: a systematic review and Meta-analysis [J]. Am J Obstet Gynecol MFM, 2023, 5(11): 101160. doi: 10.1016/j.ajogmf.2023.101160.
[10]	Liu J, Ruan FY, Cao ST, et al. Associations between prenatal multiple metal exposure and preterm birth: comparison of four statistical models [J]. Chemosphere, 2022, 289: 133015. doi: 10.1016/j.chemosphere.2021.133015.
[11]	Freire C, Amaya E, Gil F, et al. Placental metal concentrations and birth outcomes: the environment and childhood (INMA) project [J]. Int J Hyg Environ Health, 2019, 222(3): 468-478. doi: 10.1016/j.ijheh.2018.12.014.
[12]	Eaves LA, Keil AP, Jukic AM, et al. Toxic metal mixtures in private well water and increased risk for preterm birth in North Carolina [J]. Environ Health, 2023, 22(1): 69. doi: 10.1186/s12940-023-01021-7.
[13]	Zhao L, Wang SL, Liu M, et al. Maternal urinary metal(loid)s and risk of preterm birth: a cohort study in the Tibetan Plateau [J]. Environ Pollut, 2023, 333: 122085. doi: 10.1016/j.envpol.2023.122085.
[14]	Huang H, Wei LM, Chen X, et al. Cord serum elementomics profiling of 56 elements depicts risk of preterm birth: evidence from a prospective birth cohort in rural Bangladesh [J]. Environ Int, 2021, 156: 106731. doi: 10.1016/j.envint.2021.106731.
[15]	Wang ZK, Huang SD, Zhang WL, et al. Chemical element concentrations in cord whole blood and the risk of preterm birth for pregnant women in Guangdong, China [J]. Ecotoxicol Environ Saf, 2022, 247: 114228. doi: 10.1016/j.ecoenv.2022.114228.