Association between triglyceride glucose-body mass index and new-onset non-alcoholic fatty liver disease in coal miners: a retrospective cohort study

LI Yanwen; YI Shiting; LUO Yingqi; CHEN Yingtong; DAI Yingshi; LIU Yanhui; CHEN Qingsong; JIANG Liuquan; LIU Gaisheng; WU Wei; CHEN Yingjun

doi:10.16462/j.cnki.zhjbkz.2025.06.010

Volume 29 Issue 6

Jun. 2025

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2025 > 29(6): 688-696

LI Yanwen, YI Shiting, LUO Yingqi, CHEN Yingtong, DAI Yingshi, LIU Yanhui, CHEN Qingsong, JIANG Liuquan, LIU Gaisheng, WU Wei, CHEN Yingjun. Association between triglyceride glucose-body mass index and new-onset non-alcoholic fatty liver disease in coal miners: a retrospective cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 688-696. doi: 10.16462/j.cnki.zhjbkz.2025.06.010

Citation:

LI Yanwen, YI Shiting, LUO Yingqi, CHEN Yingtong, DAI Yingshi, LIU Yanhui, CHEN Qingsong, JIANG Liuquan, LIU Gaisheng, WU Wei, CHEN Yingjun. Association between triglyceride glucose-body mass index and new-onset non-alcoholic fatty liver disease in coal miners: a retrospective cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 688-696. doi: 10.16462/j.cnki.zhjbkz.2025.06.010

Citation:

LI Yanwen, YI Shiting, LUO Yingqi, CHEN Yingtong, DAI Yingshi, LIU Yanhui, CHEN Qingsong, JIANG Liuquan, LIU Gaisheng, WU Wei, CHEN Yingjun. Association between triglyceride glucose-body mass index and new-onset non-alcoholic fatty liver disease in coal miners: a retrospective cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 688-696. doi: 10.16462/j.cnki.zhjbkz.2025.06.010

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Association between triglyceride glucose-body mass index and new-onset non-alcoholic fatty liver disease in coal miners: a retrospective cohort study

doi: 10.16462/j.cnki.zhjbkz.2025.06.010

1.
Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China
2.
Department of Labour Hygiene and Environmental Hygiene, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China
3.
The Analytical and Testing Center of Institute of Occupation Disease Prevention and Control, Xishan Coal And Electricity Limited Company, Taiyuan 030053, China
4.
The Director′s Office of Institute of Occupation Disease Prevention and Control, Xishan Coal And Electricity Limited Company, Taiyuan 030053, China
5.
The Comprehensive Research Office of Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511400, China

Funds:

Coal Environmental Disease Prevention and Control Key Laboratory Project of the Ministry of Education MEKLCEPP/SXMU-202306

Guangzhou Basic and Applied Basic Research Scheme SL2023A04J02159

Guangzhou City-University (Institute)-Enterprise Joint Funding Project 2025A03J3722

More Information

Corresponding author: WU Wei, E-mail: wuw@gdiph.org.cn; CHEN Yingjun, E-mail: chenyingjun@gdpu.edu.cn
Received Date: 2024-12-27
Rev Recd Date: 2025-02-27

Available Online: 2025-07-07

Publish Date: 2025-06-10

Abstract

Abstract

Objective To explore the association between the trajectory of triglyceride glucose-body mass index (TyG-BMI) variations and the incidence of non-alcoholic fatty liver disease (NAFLD) in the coal miners. Methods We conducted a retrospective cohort study of 15 186 coal miners from Shanxi, China, who underwent at least four health check-ups between January 2, 2015 and December 29, 2023. The demographic, anthropometric, and biochemical data were collected. The group-based trajectory model was employed to identify four distinct TyG-BMI trajectory groups. The cumulative incidence of NAFLD across trajectory groups was compared using the Log-rank test, and Cox proportional hazards regression models were used to assess the association between TyG-BMI trajectories and NAFLD risk, adjusting for potential confounders. Results During the follow-up period of (5.56±1.96) years, the cumulative incidence of NAFLD in the overall population was 32.44%. The cumulative incidence of NAFLD in the low growth, moderate growth, high growth, and rapid growth TyG-BMI trajectory groups was 16.19%, 24.25%, 45.09%, and 68.78%, respectively, with significant statistical differences (all P < 0.001). Compared with the low growth group, the NAFLD risk in the moderate growth rate, high growth rate, and rapid growth rate groups increased by 0.435 times (HR=1.435, 95% CI: 1.299-1.584), 1.895 times (HR=2.895, 95% CI: 2.621-3.197), and 4.451 times (HR=5.451, 95% CI: 4.849-6.127), respectively (all P < 0.001). Subgroup analyses revealed a heightened risk of NAFLD among individuals under 40 years old, clerical staff, and those without hypertension exhibited rapid increases in TyG-BMI levels. Conclusions The trajectory of TyG-BMI levels is positively correlated with the risk of NAFLD, and a rapid increase in TyG-BMI serving as a significant risk factor for the disease′s onset. Continuous monitoring of TyG-BMI levels and timely interventions for individuals experiencing rapid increases may facilitate early prevention of NAFLD.
- Triglyceride glucose-body mass index,
- Non-alcoholic fatty liver disease,
- Trajectory,
- Retrospective cohort study,
- Coal miners

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References(18)

References

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