The association between different metabolic obesity phenotypes and gallstone disease risk

XIE Linjun; XU Yiting; WANG Xin; HE Menglin; JIANG Yi; LI Guangcan; SHAN Xuefeng; LOU Yanmei; WANG Xin

doi:10.16462/j.cnki.zhjbkz.2025.06.011

Volume 29 Issue 6

Jun. 2025

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XIE Linjun, XU Yiting, WANG Xin, HE Menglin, JIANG Yi, LI Guangcan, SHAN Xuefeng, LOU Yanmei, WANG Xin. The association between different metabolic obesity phenotypes and gallstone disease risk[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 697-705. doi: 10.16462/j.cnki.zhjbkz.2025.06.011

Citation:

XIE Linjun, XU Yiting, WANG Xin, HE Menglin, JIANG Yi, LI Guangcan, SHAN Xuefeng, LOU Yanmei, WANG Xin. The association between different metabolic obesity phenotypes and gallstone disease risk[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 697-705. doi: 10.16462/j.cnki.zhjbkz.2025.06.011

Citation:

XIE Linjun, XU Yiting, WANG Xin, HE Menglin, JIANG Yi, LI Guangcan, SHAN Xuefeng, LOU Yanmei, WANG Xin. The association between different metabolic obesity phenotypes and gallstone disease risk[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(6): 697-705. doi: 10.16462/j.cnki.zhjbkz.2025.06.011

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The association between different metabolic obesity phenotypes and gallstone disease risk

doi: 10.16462/j.cnki.zhjbkz.2025.06.011

1.
Department of Epidemiology and Biostatistics, West China School of Public Health / West China Fourth Hospital, Sichuan University, Chengdu 610041, China
2.
Department of Pharmacy, Kaizhou District People′s Hospital, Chongqing 405400, China
3.
Department of Pharmacy, Bishan Hospital of Chongqing Medical University, Chongqing 400016, China
4.
Health Risk Assessment Department, Beijing Xiaotangshan Hospital, Beijing 102211, China

Funds:

National Natural Science Foundation of China 81903398

Sichuan Provincial Science and Technology Department Outstanding Youth Science Fund 2023NSFSC1927

Sichuan Provincial Science and Technology Department Central Guide Local Science and Technology Development Special Project 2023ZYD0097

Health Research Project of Sichuan Province Chuanjian Research 2025-2401

Sichuan University "From 0 to 1" Innovation Projec 2023SCUH0026

Sichuan University 2025 Undergraduate Innovation and Entrepreneurship Training Program S202510610537

More Information

Corresponding author: WANG Xin, E-mail: wangxinmarine@126.com
Received Date: 2024-12-23
Rev Recd Date: 2025-02-24

Available Online: 2025-07-07

Publish Date: 2025-06-10

Abstract

Abstract

Objective This study aimed to investigate the association between different metabolic obesity phenotypes and the risk of gallstone disease through a nationwide multicenter cross-sectional study. Methods Participants who underwent health check-ups in four tertiary hospitals in Chongqing and Beijing from 2015 to 2020 were consecutively enrolled. A multivariate logistic regression analysis was used to compare the risk of gallstone disease among metabolically healthy non-obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO) groups. Finally, a random-effects model was employed to pool the Results from the four centers through meta-analysis. Results A total of 522 958 participants were recruited in this study, with an overall prevalence of gallstone disease of 7.5%. The prevalence of gallstone disease in the MUO, MUNO, MHO, and MHNO groups was 9.4%, 8.3%, 6.5%, and 4.2%, respectively, with statistically significant differences among the groups(all P < 0.05). Compared with the MHNO group, the risk of gallstone disease in the MHO group increased significantly by 35.8%(pooled OR=1.358; 95% CI: 1.213-1.520; P < 0.001); in the MUNO group, it increased by 34.3% (pooled OR=1.343; 95% CI: 1.211-1.489; P < 0.001); and in the MUO group, it increased by 48.9% (pooled OR=1.489; 95% CI: 1.221-1.817; P < 0.001). Subgroup analysis showed no significant differences in the association between metabolic obesity phenotypes and the risk of gallstone disease across different genders and age groups (all P>0.05). Conclusions Obesity, whether accompanied by metabolic abnormalities or not, significantly increases the risk of gallstone disease. Future efforts should focus on early screening and intervention for obese individuals, especially those with metabolic abnormalities, to reduce the burden of gallstone disease.
- Gallstones,
- Metabolic syndrome,
- Obesity

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References(25)

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