Dose-response association between lipid profiles and serum urate acid in Chinese adults

GAO Qian; LI Ting; PENG Liuqing; WANG Tong

doi:10.16462/j.cnki.zhjbkz.2023.10.005

Volume 27 Issue 10

Oct. 2023

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GAO Qian, LI Ting, PENG Liuqing, WANG Tong. Dose-response association between lipid profiles and serum urate acid in Chinese adults[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1140-1145. doi: 10.16462/j.cnki.zhjbkz.2023.10.005

Citation:

GAO Qian, LI Ting, PENG Liuqing, WANG Tong. Dose-response association between lipid profiles and serum urate acid in Chinese adults[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(10): 1140-1145. doi: 10.16462/j.cnki.zhjbkz.2023.10.005

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Dose-response association between lipid profiles and serum urate acid in Chinese adults

doi: 10.16462/j.cnki.zhjbkz.2023.10.005

Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan 030001, China; Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education, Taiyuan 030001, China

Funds:

National Natural Science Foundation of China 82204163

National Natural Science Foundation of China 82073674

Fundamental Research Program of Shanxi Province 202203021212382

More Information

Corresponding author: WANG Tong, E-mail: tongwang@sxmu.edu.cn
Received Date: 2023-03-08
Rev Recd Date: 2023-08-26

Available Online: 2023-10-23

Publish Date: 2023-10-10

Abstract

Abstract

Objective This study aims to estimate dose-response relationship of lipid profiles on serum urate acid (SUA), and to provide evidence for prevention and therapy of Hyperuricemia (HUA). Methods Based on China Health and Nutrition Survey (CHNS) in 2009 and China Health and Retirement Longitudinal Study (CHARLS) in 2011-2012, 8 509 and 6 749 participants with no missing key variables were included in this study, respectively. Generalized propensity score based inverse probability weighting (IPW) method was used to adjust for potential confounders, and to estimate dose-response curves of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) on SUA. Results In CHNS, the mean age was (50.32±15.08) years old with 15.3% of individuals having high levels of SUA. In CHARLS, the mean age was (58.52±9.17) years old and, 5.34% of individuals had high levels of SUA. Results of IPW analysis showed that there were statistically significant dose-response relationship between TG, HDL and SUA in both CHNS and CHARLS. The SUA increased as TG increased and HDL decreased. Conclusions The abnormality of lipid profiles may lead to an increase in SUA, and the timely lipid-modifying may help to prevent and treat HUA.
- Lipid profiles,
- Serum urate acid,
- Hyperuricemia,
- Dose-response relationship,
- Generalized propensity score based inverse probability weighting (IPW) method

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References(20)

References

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