维吾尔族肺结核患者肝损害的发生率及相关因素的调查

马晨晨; 翟啸虎; 秦丽岩; 顾佳怡; 毛英; 祖丽娅&#183;沙塔尔; 向阳

doi:10.16462/j.cnki.zhjbkz.2016.01.005

维吾尔族肺结核患者肝损害的发生率及相关因素的调查

doi: 10.16462/j.cnki.zhjbkz.2016.01.005

1. 新疆医科大学流行病学与卫生统计学教研室, 新疆乌鲁木齐 830011;
2. 新疆维吾尔自治区疾病预防控制中心计划免疫科, 新疆乌鲁木齐 830011

基金项目:

国家自然科学基金（30960328）

详细信息

作者简介:
马晨晨(1989-),女,回族,新疆乌鲁木齐人,在读硕士研究生。主要研究方向:传染病流行病学。

中图分类号: R521;R181.1
计量
- 文章访问数: 291
- HTML全文浏览量: 76
- PDF下载量: 49
- 被引次数: 0
出版历程
- 收稿日期: 2015-10-17
- 修回日期: 2015-11-20

Study on the incidence and risk factors of liver injury in Uighur tuberculosis patients

1. Department of Epidemiology and Health Statistics, Xinjiang Medical University, Urumqi 830011, China;
2. Department of Planned Immunization, Xinjiang Uygur Autonomous Region's Center for Disease Control and Prevention, Urumqi 830011, China

摘要

摘要: 目的了解维吾尔族肺结核患者化疗中肝损害发生情况，探讨导致肝损害可能的危险因素，为今后结核病的治疗与控制提供一定的依据。方法采用巢式病例对照研究的方法，对新疆南疆某地区1 135例维吾尔族患者进行随访及资料收集，对可能诱导抗结核药物性肝损害的相关因素进行统计分析和推论。结果抗结核药物所致肝损害（anti-tuberculosis drug induced liver injury，ATLI）的总发生率为3.08%。经单因素检验，既往有肝病史差异有统计学意义（χ²=21.273，P<0.001）；多因素非条件Logistic 回归分析显示治疗前血清转氨酶升高（OR=2.978，95% CI：1.168～7.593）和既往有肝炎病史（OR=21.852，95% CI：5.410～88.196）与ATLI的发生呈正相关。结论与发生ATLI 有关的危险因素是治疗前血清转氨酶升高和既往有肝炎病史。提示肺结核化疗强化期间，应加强检测肝功能，密切观察具有可能危险因素的患者，用药前可采取适当措施以提高治愈率。
- 抗结核药 /
- 肝 /
- 危险因素
Abstract: Objective To investigate the incidence of liver injury in Uygur patients with pulmonary tuberculosis during anti-tuberculosis chemotherapy and explore the causes of possible risk factors of liver injury, for a basis for treatment and control of tuberculosis. Methods A nested case-control study of 1 135 cases of Uygur patients were followed up and data were collected. Potential factors of ATLI were analyzed. Results Incidence of ATLI was 3.08%. The single test showed a history of liver disease was statistically significant (χ²=21.273,P<0.001). The results of multivariate Logistic regression analysis indicated that ATLI was associated with a elevated serum transaminases before treatment (OR=2.978, 95% CI:1.168-7.593) and previous history of hepatitis (OR=21.852,95% CI:5.410-88.196). Conclusions The treatment of TB patients have a elevated serum transaminases before treatment and previous history of hepatitis may be the risk factor of ATLI. In the tuberculosis patients receiving anti-TB drugs, the monitoring of liver function should be strenthened. Patients with possible risk factors should be observed closely so that appropriate measures can be taken to improve the treatment effect.
- Antituberculosis agents /
- Liver /
- Risk factors

HTML全文

参考文献(15)

Zhang F, Dou Z, Ma Y, et al. Five-year outcomes of the China national free antiretroviral treatment program [J]. AnnIntern Med, 2009,151(4):241-251.

Braitstein P, Brinkhof MW, Dabis F, et al. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy:comparison between low-come and high-income countries [J]. Lancet, 2006,367(9513):817-824.

张福杰. 国家免费艾滋病抗病毒治疗手册 [M]. 第3版. 北京:人民卫生出社, 2012:15-18.

彭国平,李旺华,占发先,等. 湖北省2715例接受艾滋病免费抗病毒治疗者生存分析 [J]. 公共卫生与预防医学, 2011,22(5):33-36.

姚世堂,段松,项丽芬,等. 云南省德宏州3103例艾滋病患者抗病毒治疗后生存分析 [J]. 中华流行病学杂志, 2010,11(31):1215-1218.

Grabar S, Le Moing V, Goujard C, et al. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy [J]. Ann Intern Med, 2000,133(6):401-410.

Cuong do D, Thorson A, Sonnerborg A, et al. Survival and causes of death among HIV-infected patients starting antiretroviral therapy in north-eastern Vietnam [J]. Scand J Infect Dis, 2012,44(3):201-208.

杨红,陈果,周良君,等. 绵阳市228例艾滋病感染者和病人CD4⁺T淋巴细胞检测分析 [J]. 中国热带医学, 2013,13(3):335-342.

原琛利,穆生财,薛子东. 山西省艾滋病抗病毒治疗死亡病例流行病学分析 [J]. 中华疾病控制杂志, 2014,18(12):1184-1186.

周琳,吴琼海,沈伟伟,等. 浙江台州市接受抗病毒治疗的艾滋病患者生存分析 [J]. 中华疾病控制杂志, 2013,17(12):1049-1051.

兰青. 人类免疫缺陷病毒/艾滋病合并乙型肝炎病毒感染的研究 [D]. 昆明:昆明医学院, 2011.

王昊鹏,杨静静,邓小昭,等. 中国大陆吸毒人群HIV、HBV、HCV感染状况及相关因素的Meta分析 [J]. 中华疾病控制杂志, 2010,14(4):300-304.

杨成彬,古贤德,罗雪文,等. 静脉吸毒艾滋病患者102例抗病毒治疗的疗效分析 [J]. 中国全科医学, 2010,13(28):3188-3190.

Alencar WK, Duarte PS, Waldman EA, et al. Survival analysis of acquired immune deficiency syndromepatients with and without hepatitis C virus infection at areference center for sexually transmitted diseases/acquiredimmune deficiency syndrome in Sao Paulo,Brazil [J]. Braz J Infect Dis, 2014,18(2):150-157.

孙定勇,王奇,杨文杰,等. 河南省2003-2009年艾滋病抗病毒治疗患者生存情况分析 [J]. 中华流行病学杂志, 2012,33(2):181-184.

施引文献

资源附件(0)

访问统计