Abstract: Objective To develop a clonorchiosis monitoring and management system in order to realize the dynamic surveillance of epidemic situation of clonorchiosis and provide prediction for disease outbreaks. Methods The system was divided into two subsystems, case report system and intermediate host monitoring system. The Browser/Server architecture was adopted as the framework in combination with Active Server Page and Microsoft access. Results User access has been opened to CDC and the relevant medical institutions under trial process in Hengxian of Guangxi and Jiamusi of Heilongjiang. Conclusions The system is believed to promote disease data collection and to be accessible to the review stage after data collection. Additionally, the system may reduce the following workflow and provide standardized data for convenience of data analysis.