城市社区老年性痴呆尿AD7c-NTP含量的分析

廖君; 马俊; 黄河浪; 闫冀; 周跃平; 吴磊

doi:10.16462/j.cnki.zhjbkz.2016.02.015

城市社区老年性痴呆尿AD7c-NTP含量的分析

doi: 10.16462/j.cnki.zhjbkz.2016.02.015

南昌大学公共卫生学院流行病学教研室, 江西南昌 330006

基金项目:

国家自然科学基金（81260441）

详细信息

作者简介:
廖君(1987-),女,江西宜春人,在读硕士研究生。主要研究方向:流行病与卫生统计学。

中图分类号: R181.2
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- 被引次数: 0
出版历程
- 收稿日期: 2015-10-15
- 修回日期: 2015-12-03

Analysis of urban community health elderly urine AD7c-NTP content

Epidemiology Teaching and Research Section, School of Public Health, Nanchang University, Nanchang 330006, China

摘要

摘要: 目的通过对城市社区60岁以上老年人群尿液中神经丝蛋白（neuronal thread protein in the urine,AD7c-NTP）含量的测定，初步探索其在老年性痴呆（alzheimer's disease,AD）早期筛查诊断中的价值。方法采用酶联免疫吸附测定法（enzyme-linked immunosorbent assay,ELISA），检测病例组（86例）与年龄、性别相匹配的对照组（172例）尿液中AD7c-NTP的含量，绘制ROC曲线，计算灵敏度与特异度。结果病例组尿AD7c-NTP值平均为（2.32±1.38）ng/ml，对照组尿AD7c-NTP值平均为（0.86±0.62）ng/ml，两组间差异具有统计学意义（t=9.383，P<0.001）；ROC曲线下的面积为0.854，当临界值选定为1.313 ng/ml时，灵敏度为84.9%，特异度为70.3%。结论尿液中AD7c-NTP的含量可作为AD早期筛查诊断的生化指标。
- 老年人 /
- 阿尔茨海默病 /
- ROC曲线
Abstract: Objective To measure the content of neuronal thread protein in the urine (AD7c-NTP) of urban community elderly who are over 60 years, and to explore the value in the early screening and diagnosis of Alzheimer's disease (AD). Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the contents of urine AD7c-NTP between the case group (86 cases) and age-matched control group (172 cases), then ROC curve was drawn and sensitivity and specificity were calculated. Results The average levels of AD7c-NTP in case group were (2.32±1.38) ng/ml, and in the control group were (0.86±0.62) ng/ml. The difference between the two groups was statistically significant(t=9.383,P<0.001); The area under the ROC curve was 0.854. When the threshold was selected as 1.313 ng/ml, the sensitivity was 84.9%, and specificity was 70.3%. Conclusions The levels of AD7c-NTP in the urine can be used as biological indicators of early screening and diagnosis of AD.
- Aged /
- Alzheimer disease /
- ROC curve

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参考文献(18)

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