维生素D受体和核转录因子-κB p65在人结肠癌组织中的表达

陈秀明; 魏清; 张程; 王华; 陈远华; 徐德祥

doi:10.16462/j.cnki.zhjbkz.2016.03.009

维生素D受体和核转录因子-κB p65在人结肠癌组织中的表达

doi: 10.16462/j.cnki.zhjbkz.2016.03.009

陈秀明^1,2,
魏清^1,2,
张程¹,
王华¹,
陈远华¹,
徐德祥^1, ,

1. 安徽医科大学卫生毒理学系, 安徽合肥 230032;
2. 皖西卫生职业学院病理学教研室, 安徽六安 237005

基金项目:

国家自然科学基金（81373495,81172711）

详细信息

作者简介:
陈秀明(1965-),女,安徽合肥人,讲师,在读硕士研究生。主要研究方向:肿瘤病理诊断。

中图分类号: R735.35; R181
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出版历程
- 收稿日期: 2015-11-27
- 修回日期: 2016-01-17

The expression of vitamin D receptor and nuclear factor-κB p65 in human colon cancer

1. Department of Toxicology, Anhui Medical University, Hefei 230032, China;
2. Department of Pathology, West Anhui Health Vocational College, Lu'an 237005, China

摘要

摘要: 目的研究维生素D受体（vitamin D receptor，VDR）和核转录因子（nuclear factor，NF）-κB p65在人结肠癌组织中的表达水平。方法收集手术切除的结肠癌和对照标本各27例为研究对象，采用免疫组织化学技术检测对照和癌组织VDR和NF-κB p65表达状况。结果 27例结肠癌患者中有5例VDR表达阳性（18.5%），有7例NF-κB p65表达阳性（25.9%）；对照组有23例VDR表达阳性（85.2%）, 有25例NF-κB p65表达阳性（92.6%）。人结肠癌组织VDR和NF-κB p65阳性表达均低于对照组，差异有统计学意义（均有P<0.001）。结论人结肠癌组织中VDR和NF-κB p65表达呈低水平。
- 结肠肿瘤 /
- 受体,骨化三醇 /
- 转录因子RelA
Abstract: Objective To explore the expression of vitamin D receptor(VDR) and nuclear factor(NF)-κB p65 in human colon cancer.Methods The expression of VDR and NF-κB in the surgically resected tissue specimens from 27 cases and the normal tissue from 27 people of control were detected by immunohistochemistry.Results The VDR expression of 5 cases (18.5%) and NF-κB p65 of 7 cases(25.9 %) was positive in the specimens of 27 cases, but VDR expression of 23 cases (85.2%) and NF-κB p65 of 25 cases(92.6%) was positive in the specimens of 27 control. The positive expression of VDR and NF-κB p65 in human colon cancer was lower than that in control (all P<0.001). Conclusions The expression of VDR and NF-κB p65 is low in human colon cancer.
- Colonic neoplasms /
- Receptors, calcitriol /
- Transcription factor RelA

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参考文献(19)

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