体力活动与女性乳腺癌发病关系的病例对照研究

杜雨峰; 罗伟平; 严波; 莫雄飞; 徐铭; 张彩霞

doi:10.16462/j.cnki.zhjbkz.2016.03.010

体力活动与女性乳腺癌发病关系的病例对照研究

doi: 10.16462/j.cnki.zhjbkz.2016.03.010

1. 中山大学公共卫生学院医学统计与流行病学系, 广东广州 510080;
2. 中山大学附属第一医院甲状腺乳腺外科, 广东广州 510080

基金项目:

国家自然科学基金（81102188）；广州市科技计划项目科学研究专项（201510010151）

详细信息

作者简介:
杜雨峰(1989-),男,甘肃定西人,在读硕士研究生。主要研究方向:慢性病流行病学。

中图分类号: R737.9;R181.1
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- 被引次数: 0
出版历程
- 收稿日期: 2015-11-18
- 修回日期: 2016-01-10

Physical activity and breast cancer risk: a case-control study

1. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China;
2. Department of Thyroid Breast Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China

摘要

摘要: 目的探讨体力活动与乳腺癌发病的关系。方法采用以医院为基础的病例对照研究，调查某大学2所附属医院2012年4月~2014年12月间确诊的25～70岁549例乳腺癌患者和同期同医院就诊的549例非肿瘤患者的体力活动情况和相关危险因素。采用非条件Logistic回归模型分析体力活动与乳腺癌发病的关系。结果校正各种混杂因素后，非职业性体力活动与乳腺癌发病风险降低有关（OR=0.69,95% CI：0.48～1.00）；与不参加体育活动者相比，参加体育活动对乳腺癌发病有保护作用（OR=0.61,95% CI：0.43～0.87）；与久坐不动的职业相比，轻度职业活动对乳腺癌发病有保护作用（OR=0.67,95% CI：0.47～0.97），而家务活动与乳腺癌发病风险无关。不同雌激素受体（estrogen receptor，ER）和孕激素受体（progesterone receptor，PR）状态的亚组分析中，非职业性体力活动与ER+/PR+乳腺癌的发病风险降低有关。结论非职业性体力活动、体育活动和轻度职业活动对女性乳腺癌有保护作用。
- 乳腺肿瘤 /
- 病例对照研究 /
- 流行病学研究
Abstract: Objective To assess the association between physical activity and risk of breast cancer. Methods A hospital-based case-control study was conducted in two affiliated hospitals of a university between April 2012 and December 2014. Face to face interviews were completed among 549 breast cancer cases and 549 controls. Physical activity and potential risk factors of breast cancer were collected by using a standard questionnaire. Multivariate unconditional Logistic regression model was used to estimate the association between physical activity and breast cancer risk. Results A lower risk for breast cancer was observed for highest levels of non-occupational physical activity (OR=0.69,95% CI:0.48-1.00), for recreational activity (OR=0.61, 95% CI:0.43-0.87), as well as for standing occupational activity (OR=0.67, 95% CI:0.47-0.97), while household activity showed null result. Non-occupational physical activity showed reverse association with ER+/PR+ breast cancer risk. Conclusions Non-occupational physical activity, recreational activity and standing occupational activity are inversely associated with breast cancer risk.
- Breast neoplasms /
- Case-control studies /
- Epidemiologic studies

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参考文献(19)

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