Epidemiological advance of middle east respiratory syndrome coronavirus infection
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摘要: 中东呼吸综合征冠状病毒(middle east respiratory syndrome coronavirus,MERS-CoV)能引起人的下呼吸道感染,病死率高,对全球公共卫生造成了威胁。从2012年发现MERS-CoV至今,已经有26个国家出现过MERS-CoV病毒感染,截至2016年2月19日WHO报告的实验室确诊病例有1 638例,其中死亡病例587例。本综述对MERS-CoV的一般病毒学特点、致病机制进行了阐述,同时对MERS-CoV与严重急性呼吸系统综合征冠状病毒的流行病学特点进行了比较。Abstract: The middle east respiratory syndrome coronavirus (MERS-CoV) causes a severe lower respiratory tract infection in humans with high mortality, it has posed a serious global thereat to the public health. Since its discovery in 2012, MERS-CoV has reached 26 countries, as of 19 February 2016 WHO has been notified of 1 638 laboratory-confirmed cases of infection with MERS-CoV, including at least 587 related death. In this review, we highlighted the knowledge on MERS-CoV in general virology and mechanism of pathogeny, and compared MERS-CoV with SARS-CoV on the epidemiology.
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Key words:
- SARS virus /
- Coronavirus /
- Epidemiology /
- Middle east respiratory syndrome
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Cunha CB, Opal SM. Middle East respiratory syndrome (MERS): A new zoonotic viral pneumonia [J]. Virulence, 2014,5(6):650-654. Jadav HA. Middle East Respiratory Syndrome-Corona Virus (MERSCoV): A Deadly Killer [J]. IOSR JPBS, 2013,8(5):74-81. de Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group [J]. J Virol, 2013, 87 (14):7790-7792. lvarez E, Donado-Campos J, Morilla F. New coronavirus outbreak. Lessons learned from the severe acute respiratory syndrome epidemic [J]. Epidemiol Infect, 2015,143(13):2882-2893. Van Boheemen S, de Graaf M, Lauber C, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans [J]. MBio, 2012,3(6):e473-412. Cotton M, Lam TT, Watson SJ, et al. Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus [J]. Emerg Infect Dis, 2013,19(5):736-742B. Woo PC, Lau SK, Li KS, et al. Genetic relatedness of the novel human group C betacoronavirus toTylonycterisbat coronavirus HKU4 andPipistrellusbat coronavirus HKU5 [J]. Emerg Microbes Infect, 2012,1(11):e35. Frey KG, Redden CL, Bishop-Lilly KA, et al. Full-genome sequence of human betacoronavirus 2c jordan-n3/2012 after serial passage in mammalian cells [J]. Genome Announc, 2014,2(3):e324-314. Qian Z, Dominguez SR, Holmes KV. Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation [J]. PLoS One, 2013,8(10):e76469. Yang Y, Zhang L, Geng H, et al. The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists [J]. Protein Cell, 2013,4(12):951-961. Siu KL, Yeung ML, Kok KH, et al. Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response [J]. J Virol, 2014,88(9):4866-4876. Matthews KL, Coleman CM, van der Meer Y, et al. The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signaling [J]. J Gen Virol, 2014(Pt 4),95:874-882. Niemeyer D, Zillinger T, Muth D, et al. Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist [J]. J Virol, 2013,87(22):12489-12495. Yang X, Chen X, Bian G, et al. Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease [J]. J Gen Virol, 2014,95(Pt3):614-626. Chan JF, Lau SK, To KK, et al. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease [J]. Clin Microbiol Rev, 2015,28(2): 465-522. Raj VS, Mou H, Smits SL, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC [J]. Nature, 2013,495(7440):251-254. Banik GR, Khandaker G, Rashid H. Middle East respiratory syndrome coronavirus "MERS-CoV": current knowledge gaps [J]. Paediatr Respir Rev, 2015,16(3):197-202. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study [J]. Lancet Infect Dis, 2013,13(9):752-761. Drosten C, Meyer B, Muller MA, et al. Transmission of MERS-coronavirus in household contacts [J]. N Engl J Med, 2014,371(9):828-835. Al-Abdallat MM, Payne DC, Alqasrawi S, et al. Hospital-associated outbreak of middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description [J]. Clin Infect Dis, 2014,59(9):1225-1233. Breban R, Riou J, Fontanet A. Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk [J]. Lancet, 2013,382(9893):694-699. Alqurashi KA, Aljabri KS, Bokhari SA. Prevalence of diabetes mellitus in a Saudi community [J]. Ann Saudi Med, 2011,31(1):19-23. Zumla AI, Memish ZA. Middle East respiratory syndrome coronavirus: epidemic potential or a storm in a teacup? [J]. Eur Respir J, 2014,43(5):1243-1248. Gierer S, Hofmann-Winkler H, Albuali WH, et al. Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia [J]. Emerg Infect Dis, 2013,19(12):2034-2036. Aburizaiza AS, Mattes FM, Azhar EI, et al. Investigation of anti-Middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, fall 2012 [J]. J Infect Dis, 2014,209(2):243-246. Lau SK, Li KS, Tsang AK, et al. Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus [J]. J Virol, 2013,87(15):8638-8650. Yang Y, Du L, Liu C, et al. Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus [J]. Proc Natl Acad Sci USA, 2014,111(34):12516-12521. Wang Q, Qi J, Yuan Y, et al. Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 [J]. Cell Host Microbe, 2014,16(3):328-337. Lau SK, Li KS, Tsang AK, et al. Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to pomona leafnosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders [J]. J Virol, 2012,86(21):11906-11918. Cui J, Eden JS, Holmes EC, et al. Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): implications for the origin and emergence of Middle East respiratory syndrome coronavirus [J]. Virol J, 2013,10:304. Memish ZA, Mishra N, Olival KJ, et al. Middle East respiratory syndrome coronavirus in bats, Saudi Arabia [J]. Emerg Infect Dis, 2013,19(11):1819-1823. Ithete NL, Stoffberg S, Corman VM, et al. Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa [J]. Emerg Infect Dis, 2013,19(10):1697-1699. Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study [J]. Lancet, 2013,382(9909):1993-2002. Cotten M, Watson SJ, Zumla AI, et al. Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus [J]. MBio, 2014,5(1):pii:e01062-13. Briese T, Mishra N, Jain K, et al. Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia [J]. MBio, 2014,5(3):e1146-1114.
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