青岛成人抑郁症和2型糖尿病患病率双向关联研究

宁锋; 王玉美; 孙晓晖; 张栋; 辛化雷; 南海荣; 乔青; 汪韶洁; 司茜; 高汝钦; 逄增昌

doi:10.16462/j.cnki.zhjbkz.2016.04.009

青岛成人抑郁症和2型糖尿病患病率双向关联研究

doi: 10.16462/j.cnki.zhjbkz.2016.04.009

宁锋¹,
王玉美²,
孙晓晖¹,
张栋³,
辛化雷¹,
南海荣⁴,
乔青⁵,
汪韶洁^1, ,,
司茜⁶,
高汝钦¹,
逄增昌¹

1. 青岛市疾病预防控制中心慢性病防制科, 山东青岛 266033;
2. 青岛市传染病医院第十病区, 山东青岛 266033;
3. 青岛市黄岛区疾病预防控制中心慢性病防制科, 山东青岛 266033;
4. 香港大学公共卫生学院糖尿病组, 香港特别行政区 999077;
5. 芬兰赫尔辛基大学公共卫生学院糖尿病组, 芬兰赫尔辛基 00014;
6. 青岛市卫生监督局第五处室, 山东青岛 266033

基金项目:

世界糖尿病基金（WDF05-108&07-308）；青岛市优秀青年医学人才科研专项（2014）

详细信息

作者简介:
宁锋(1980-),男,山东章丘人,主管技师,博士。主要研究方向:营养与慢病防制。

中图分类号: R749.42;R587.1
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出版历程
- 收稿日期: 2015-12-20
- 修回日期: 2016-02-20

Bi-direction association on the increased prevalence of depression and type 2 diabetes among adults in Qingdao

1. Department of Chronic Disease Control and Prevention, Qingdao Center for Disease Control and Prevention, Qingdao 266033, China;
2. Department of the 10th Ward of Hepatopathy, Qingdao Infectious Disease Hospital, Qingdao 266033, China;
3. Department of Chronic Disease Control and Prevention, Huangdao Center for Disease Control and Prevention, Qingdao 266033, China;
4. Diabetes Unit, Department of Public Health, HongKong University, HongKong SAR 999077, China;
5. Diabetes Unit, Department of Public Health, University of Helsinki, Helsinki 00014, Finland;
6. Department of the 5th Section, Qingdao Health Supervision Bureau, Qingdao 266033, China

摘要

摘要: 目的评估青岛成人抑郁和2型糖尿病的患病率以及相关危险因素，为社区开展早期慢性病危险因素预防提供科学依据。方法研究对象来自青岛市2006年建立的横断面研究数据，通过分层随机抽样抽取6 100名35～74岁常住居民（居住时间≥5年）。用Zung自评量表进行抑郁的筛检，标准2 h糖耐量试验诊断糖尿病。结果 2 974名调查者纳入本研究，抑郁和2型糖尿病的患病率分别为10.1%和16.4%。多因素校正Logistic回归分析中，糖尿病增加抑郁患病风险，农村居民、高密度脂蛋白降低抑郁的风险（均有P<0.05）；年龄、抑郁、体质指数、甘油三酯、高血压、糖尿病家族史、未婚与2型糖尿病患病率增长均呈正相关（均有P<0.05）；空腹血糖与抑郁（χ²=12.32,OR=1.366，95% CI:1.151～1.622）、2 h血糖与抑郁（χ²=11.35,OR=1.212,95% CI:1.081～1.358）皆存在剂量-反应关系。结论抑郁和2型糖尿病互为两者患病率增加的独立危险因素。早期开展社区心理干预能够预防抑郁和糖尿病的发生。
- 抑郁 /
- 糖尿病,2型 /
- 危险因素 /
- 患病率
Abstract: Objective To evaluate the prevalence of depression and type 2 diabetes and related risk factors among adults in Qingdao, to provide evidence on early psychological intervention on communities and prevention of chronic disease risk factors. Methods A population-based cross-sectional study was conducted in Qingdao, China in 2006. A stratified random cluster sampling procedure was employed to recruit 6 100 participants aged 35-74 years living in Qingdao for at least 5 years. The Zung self-assessment score was employed to assess depression, and diabetes classification were applied using a standard oral glucose tolerance test. Results A total of 2 974 study subjects was included in the data analysis, with prevalences of depression and type 2 diabetes of 10.1% and 16.4%, respectively. Type 2 diabetes were related to depression, rural residents and high density lipoprotein-cholesterol were reversely associated with depression (all P<0.05). Age, depression, BMI, serum triglycerides, hypertension, family history of diabetes and unmarried status were significantly associated with increased prevalence of type 2 diabetes in a multivariable logistic regression model(all P<0.05). There was a dose-response relationship between fasting, 2 h plasma glucose and depression. The corresponding figures were χ²=12.32,OR=1.366 (95% CI:1.151-1.622) and χ²=11.35,OR=1.212 (95% CI:1.081-1.358), respectively. Conclusions Type 2 diabetes and depression is an independent risk factor for depression and type 2 diabetes prevalence in Chinese community, respectively. Early identification and lifestyle intervention may prevent individuals from depression and diabetes.
- Depression /
- Diabetes mellitus, type 2 /
- Risk factors /
- Prevalence

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参考文献(16)

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