Analysis on quality of life/patient-reported outcomes and their influence factors in patients with rheumatoid arthritis:applications of QLICD-RA(V2.0)
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摘要: 目的 探究影响类风湿关节炎患者生命质量/患者报告结局的因素，为提高患者生命质量提供科学依据。方法 应用类风湿关节炎生命质量测定量表（quality of life instruments for chronic diseases in rheumatoid arthritis （version 2.0），QLICD-RA（V 2.0））调查100例住院患者的生命质量，并记录临床相关客观指标。应用t检验、方差分析、多元逐步回归等统计学方法分析影响类风湿关节炎患者生命质量/患者报告结局的因素。结果 单因素分析中，不同文化程度和家庭经济状况的患者生命质量总分及各领域得分差异均有统计学意义（均有P<0.05）。多元逐步回归分析中，筛选出28关节中的关节肿胀得分（disease activity score-28,DAS28）、家庭经济状况（economy conditions, EC）和天门冬氨酸氨基转移酶（aspartate aminotransferase，AST）与丙氨酸氨基转移酶（alanine aminotransferase，ALT）比值（AST/ALT）这3个变量进入回归方程，其回归方程为：Y=55.239-1.390DAS28+12.729EC-4.491AST/ALT，调整决定系数Ra2=0.558。结论 类风湿关节炎患者生命质量/患者报告结局受多种因素影响，缓解患者症状、提高经济水平对提高类风湿关节炎患者的生命质量/患者报告结局有重要意义。Abstract: Objective To analyze the quality of life/patient-reported outcomes and their influence factors in patients with rheumatoid arthritis for the establishment of related policies to improve the patients'quality of life. Methods The quality of life instruments for chronic diseases in rheumatoid arthritis (version 2.0)(QLICD-RA(V2.0)) was used to survey 100 in-patients with rheumatoid arthritis, and the clinical objective indicators were recorded. The influence factors of the quality of life or patient-reported outcomes were analyzed by methods of t-test, analysis of variance and multiple stepwise regression. Results In single factor analysis,the total and each domain score of quality of life among different education levels and the family economic conditions were significantly different (all P<0.05). In multiple factors analysis, disease activity score-28(DAS28), family economic conditions(EC) and aspartate aminotransferase(AST)/alanine aminotransferase(ALT) were selected into the regression equation: Y=55.239-1.390DAS28+12.729EC-4.491AST/ALT, and the adjusted coefficient of decision Ra2=0.558. Conclusions The quality of life/patient-reported outcomes were influenced by a number of factors. It is of significance to improve patients' quality of life by relieving symptoms and improving the level of economic.
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Key words:
- Arthritis, rheumatoid /
- Quality of life /
- Epidemiologic studies
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