Risk factors of degree of cerebral artery stenosis in patients with ischemic vascular disease
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摘要: 目的 探讨常见的缺血性脑血管狭窄严重程度的影响因素。方法 将160例行脑血管造影术检查的缺血性脑血管病患者按血管狭窄严重程度分成轻、中、重度狭窄三组,采用多元Logistic回归进行分析,寻找引起脑动脉狭窄严重程度的影响因素。结果 年龄、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、糖尿病、高血压、同型半胱氨酸(homocysteine, Hcy)水平在不同程度狭窄组中比较差异具有统计学意义(均有P<0.05),其中年龄和LDL-C在重度狭窄组高于中度狭窄和轻度狭窄组(均有P<0.05),Hcy在重度狭窄组高于轻度狭窄组(P<0.05);Logistic回归分析发现年龄(OR=0.061, P<0.001)及高血脂(OR=0.435, P=0.003)是血管狭窄程度的危险因素;相对于糖尿病患者,非糖尿病者是血管狭窄程度的保护因素(OR=-0.821, P=0.009)。结论 年龄、高血脂是血管狭窄程度的危险因素,而非糖尿病则是保护因素。
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黄治飞,朱幼玲,朱双根,等. 缺血性脑卒中患者颅内外脑动脉狭窄的分布及其危险因素分析 [J]. 中华老年心脑血管病杂志, 2015,17(15),451-454. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis [J]. N Engl J Med, 1991,325 (7):445-453. Tsantilas P, Kühnl A, Kallmayer M, et al. Stroke risk in the early period after carotid related symptoms: a systematic review [J]. J Cardiovasc Surg (Torino), 2015,56(6):845-852. Kalashnikova LA, Konovalov RN, Dobrynina LA. Ischemic stroke due to isolated spontaneous posterior cerebral artery dissection in young adults [J]. Zh Nevrol Psikhiatr Im S S Korsakova, 2009, 109(5 Suppl 2):3-10. Chiavaroli L, de Souza RJ, Ha V,et al. Effect of fructose on established lipid targets: A systematic review and meta-Analysis of controlled feeding trials [J]. Am Heart Assoc, 2015,4(9):e001700. 肖利杰,龚爱平, 魏秀娥. 脑梗死与血脂,血尿酸水平的相关分析 [J]. 医学理论与实践, 2012,25(24):3077-3078. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease:a common mutation in methylenetetrahydrofolate reductase [J]. Nat Genet, 1995, 10(1):111-113. Robinson JG. Models for describing relations among the various stain drugs, low-density lipoprotein cholesterol lowering, pleiotropic effects, and cardiovascular risk [J]. Am J Cardiol, 2008,101(7):1009-1015. He Y, Li Y, Chen Y, et al. Homocysteine level and risk of different stroke types: a meta-analysis of prospective observational studies [J]. Nutr Metab Cardiovasc Dis, 2014,24(11):1158-1165. Jeong SK, Seo JY, Cho YI. Homocysteine and internal carotid artery occlusion in ischemic stroke [J]. Atheroscler Thromb, 2010,17(9):963-969. 王雪茵,胡永华. 同型半胱氨酸代谢与脑卒中关系的研究进展 [J]. 中华疾病控制杂志, 2013,17(11):988-992.
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