流行性乙型脑炎减毒活疫苗加强免疫的Meta分析

承晓华; 王诗远; 刘元宝; 杨维维; 刘沛

doi:10.16462/j.cnki.zhjbkz.2016.07.017

流行性乙型脑炎减毒活疫苗加强免疫的Meta分析

doi: 10.16462/j.cnki.zhjbkz.2016.07.017

1. 东南大学公共卫生学院教研室流行病与生物统计教研室, 江苏南京 210009;
2. 江苏省疾病预防控制中心免疫规划所, 江苏南京 210009

基金项目:

“十二五”国家科技重大专项（2011ZX10004-902）

详细信息

作者简介:
承晓华(1989-),女,满族,江苏太仓人,在读硕士研究生。主要研究方向:生物统计学。

中图分类号: R512.32
计量
- 文章访问数: 379
- HTML全文浏览量: 72
- PDF下载量: 33
- 被引次数: 0
出版历程
- 收稿日期: 2015-12-15
- 修回日期: 2016-04-25

Immunization efficacy of Japanese encephalitis live attenuated vaccine booster dose:a Meta-analysis

1. Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China;
2. Department of Immunization Program, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China

摘要

摘要: 目的系统评价乙脑减毒活疫苗加强免疫效果并探讨其必要性。方法计算机检索中国知网、万方数据知识服务平台、Cochrane Database 、PubMed、Web of Science数据库，收集乙脑减毒活疫苗加强免疫的研究，检索时限均为从建库至2015年3月。由2名研究者按照纳入与排除标准筛选文献、提取资料和评价纳入研究的方法学质量，使用Stata 12.0 软件进行统计计算。结果总共纳入9篇文献。Meta分析结果显示：基础免疫后一个月合并阳性率为79%（95% CI：69%～90%）,基础免疫一年后，接种者的抗体水平下降（合并阳性率51%，95% CI：17%～86%），加强免疫后抗体水平明显升高（合并阳性率98%，95% CI：97%～99%）。结论乙脑减毒活疫苗加强免疫能提高人群乙脑抗体阳性率和抗体平均几何滴度，有利于达到对人群长期保护的目的。
- 脑炎, 日本 /
- 疫苗,减毒 /
- Meta分析
Abstract: Objective To systematically review the immunization efficacy of Japanese encephalitis live attenuated vaccine booster dose among children. Methods Databases including China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed, Web of Science, Cochrane Library were searched for studies on Japanese encephalitis live attenuated vaccine booster dose. According to the inclusion and exclusion criteria, individual studies were selected by reviewing literatures. Data were aggregated and methodological quality of primary studies was assessed. Meta-analysis was performed using Stata 12.0. Results Nine studies were included in the final meta-analysis. Results showed that the pooled positive rate was (79%; 95% CI: 69%-90%) after the first vaccination and decreased sharply one year later (51%; 95% CI: 17%-86%)). The pooled positive rate increased significantly after a booster dose (98%; 95% CI: 97%-99%). Conclusions Positive rate and GMT of among intervals between first vaccination, one year after first vaccination and booster dose are statistically significant. A booster dose provides better protection against Japanese encephalitis with a higher serological effect.
- Encephalitis, Japanese /
- Vaccines, attenuated /
- Meta-analysis

HTML全文

参考文献(29)

World Health Organization. Japanese encephalitis vaccines [J]. Wkly Epidemiolo Rec, 2006,73(44):331-340.

Umenai T, Krzysko R, Bektimirov TA, et al. Japanese encephalitis: current worldwide status [J]. Bull World Health Organ, 1985,63(4):625-631.

蔡宝祥. 我国流行性乙型脑炎研究近况 [J]. 畜牧与兽医, 2012,44(7):1-5.

Misra UK, Kalita J. Overview: Japanese encephalitis [J]. Prog Neurobiol, 2010,91(2): 108-120.

俞永新. 基于SA14-14-2减毒株的新型乙型脑炎疫苗的研究进展 [J]. 中国病毒病杂志, 2012,2(3):161-168.

俞永新. 流行性乙型脑炎减毒活疫苗的发展和应用 [J]. 上海预防医学杂志, 2006,18(3):110-112.

Kumar R, Tripathi P, Rizvi A. Effectiveness of one dose of SA14-14-2 vaccine against Japanese encephalitis [J]. N Engl J Med, 2009,360(14): 1465-1466.

Chokephaibulkit K, Sirivichayakul C, Thisyakorn U, et al. Safety and immunogenicity of a single administration of live-attenuated Japanese encephalitis vaccine in previously primed 2- to 5-year-olds and naive 12- to 24-month-olds: multicenter randomized controlled trial [J]. Pediatr Infect Dis J, 2010,29(12):1111-1117.

Feroldi E, Pancharoen C, Kosalaraksa P, et al. Single-dose, live-attenuated Japanese encephalitis vaccine in children aged 12-18 months:randomized, controlled phase 3 immunogenicity and safety trial [J]. Hum Vaccin Immunother, 2012,8(7):929-937.

张振华,康菊琴,柳建茹,等. 流行性乙型脑炎减毒活疫苗与灭活疫苗免疫效果及人体接种反应观察 [J]. 宁夏医学杂志, 2012,34(7):632-633.

Palys KE, Berger VW. A note on the Jadad score as an efficient tool for measuring trial quality [J]. J Gastrointest Surg, 2013,17(6):1170-1171.

Dersimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: An update [J]. Contemp Clin Trials, 2007,28(2):105-114.

李宝贵,梁子明,郑彩霞. “几何标准差”辨析 [J]. 中国卫生统计, 1994,11(6):54.

严有望. 抗体几何平均滴度计算中如何处理抗体阴性者? [J]. 微生物学免疫学进展, 2000,28(4):98-100.

刘关键,吴泰相. Meta分析的森林图及临床意义 [J]. 中国循证医学杂志, 2004,4(3):198-201.

Choi UY, Lee SY, Kim KH, et al. Is a booster dose necessary in children after immunization with live attenuated Japanese encephalitis vaccine? [J]. J Trop Pediatr, 2013,59(5):423-425.

Chotpitayasunondh T, Sohn Y, M Yoksan S, et al. Immunizing children aged 9 to 15 months with live attenuated SA14-14-2 Japanese encephalitis vaccine in Thailand [J]. J Med Assoc Thai, 2011,94(Suppl 3):S195-203.

敖坚,俞永新,武佩芬,等. 流行性乙型脑炎病毒的变异——Ⅶ.乙型脑炎SA(14-5-3)株减毒活疫苗免疫后抗体持久性观察 [J]. 微生物学报, 1981,21(4):501-505.

郭绍红,闫绍宏,陈海平,等. 冻干精制Vero细胞流行性乙型脑炎灭活疫苗在低流行区的人体反应及免疫效果 [J]. 中国计划免疫, 2002,8(6):330-332.

郭万申,李林村,吴振溢,等. 两种乙型脑炎疫苗的免疫效果观察 [J]. 中华流行病学杂志, 1998,19(2):97-99.

纪文艳,张合润,孙美平,等. 流行性乙型脑炎减毒活疫苗免疫效果观察 [J]. 中国预防医学杂志, 2008,9(8):755-756.

贾丽丽,俞永新, Shin sunheang,等. 流行性乙型脑炎减毒活疫苗人群接种后中和抗体持久性观察 [J]. 中国计划免疫, 2003,9(2):111-113.

李万军,王世清,王志勇, 等. 两种流行性乙型脑炎疫苗的安全性和免疫效果观察 [J]. 实用预防医学, 2007,14(3):699-701.

马福宝,郑理,毕诚,等. 乙脑灭活与减毒活疫苗联合免疫的前瞻性研究 [J]. 实用预防医学, 2003,10(5):632-634.

Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? [J]. Lancet, 1998,352(9128):609-613.

王华庆,随海田,梁晓峰. Meta分析在疫苗评价中的应用 [J]. 中国计划免疫, 2007,13(6):600-604.

尹遵栋,罗会明,李艺星,等. 流行性乙型脑炎疫苗基础免疫血清学效果的Meta分析 [J]. 中国疫苗和免疫, 2009,15(6):501-506.

Schioler KL, Samuel M, Wai KL. Vaccines for preventing Japanese encephalitis [J]. Cochrane Database Syst Rev, 2007,12(3):CD004263.

Xin YY, Ming ZG, Peng GY, et al. Safety of a live-attenuated Japanese encephalitis virus vaccine (SA14-14-2) for children [J]. Am J Trop Med Hyg, 1988,39(2):214-217.

施引文献

资源附件(0)

访问统计