影响淋巴瘤病理诊断的临床因素分析

陈文俊; 宋耕; 李泽清; 吴秀伟; 李昌正; 王年飞; 吴强; 陈振东

doi:10.16462/j.cnki.zhjbkz.2016.07.019

影响淋巴瘤病理诊断的临床因素分析

doi: 10.16462/j.cnki.zhjbkz.2016.07.019

1. 安徽医科大学第二附属医院肿瘤内科, 安徽合肥 230000;
2. 安徽医科大学基础医学院病理教研室, 安徽合肥 230000

基金项目:

国家自然科学基金（81402427）

详细信息

作者简介:
陈文俊(1987-),女,安徽马鞍山人,在读硕士研究生。主要研究方向:肿瘤综合治疗。

中图分类号: R733.1;R181.2
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- 被引次数: 0
出版历程
- 收稿日期: 2015-11-13
- 修回日期: 2016-04-10

Analysis of clinical factors influencing pathologic diagnosis in lymphoma

1. Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230000, China;
2. Department of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230000, China

摘要

摘要: 目的基于临床角度研究影响淋巴瘤病理诊断与临床诊断不一致的因素及其对治疗的影响。方法收集我科2012年1月1日~2014年12月31日232例临床或病理诊断淋巴瘤患者的临床资料，研究淋巴瘤病理诊断与临床诊断不一致的原因及对治疗的影响。结果结内淋巴瘤和弥漫大B细胞淋巴瘤病理诊断的可靠性分别高于结外淋巴瘤和非弥漫大B细胞淋巴瘤。不同取材方式对病理诊断可靠性也有影响，切除活检的肯定性病理报告率最高为73.7%。病理诊断与临床诊断不一致14例（6.0%），3例对治疗产生中度影响，剩余11例产生轻微影响。诊断差异主要与病变部位、取材方式及淋巴瘤病理类型有关。结论淋巴瘤病理诊断与临床诊断不一致主要是淋巴瘤本身病理诊断即十分困难，此外病灶位置与取材方式也会影响病理诊断的可靠性，临床医生应与病理专家充分沟通，争取更准确的诊断。
- 淋巴瘤 /
- 诊断 /
- 流行病学方法
Abstract: Objective To explore factors influencing the discrepancy between clinical and pathological lymphoma diagnosis and their effects on the lymphoma treatment. Methods 232 hospitalized patients clinically or pathologically diagnosed with lymphoma between January 1st, 2012 and December 31st, 2014 were included in this study. The discrepancy between clinical and pathological diagnosis was assessed and the effects on the lymphoma treatment was evaluted. Results The diagnostic reliabilities of nodal lymphoma and diffuse large B-cell lymphoma were higher than those in extra-nodal lymphoma and non-diffuse large B cell lymphoma respectively. Reliability of pathological diagnosis was affected by diagnostic methods whereby the highest reliability incision biopsy could be 73.7%. There were 14(6.0%) inconsistent cases between clinical and pathological diagnosis, three cases resulted in moderate effects and 11 cases lead to mild effects on treatment. Inconsistencies were mainly due to lesion locations, different pathological diagnostic methods and pathological types of lymphoma. Conclusions The difficulty of lymphoma diagnosis, the locations and pathological diagnostic methods of lymphoma may contribute to the discrepancy between clinical and pathological diagnosis of lymphoma. Effective communication between clinicians and pathologist is required to get a more accurate diagnosis of lymphoma.
- Lymphoma /
- Diagnosis /
- Epidemiologic methods

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