北京地区不同人群柯萨奇病毒A16型和肠道病毒71型感染状况调查

李洁; 林长缨; 贾蕾; 杨扬; 杜轶威; 梁志超; 刘园; 陈丽娟; 王全意

doi:10.16462/j.cnki.zhjbkz.2016.08.004

北京地区不同人群柯萨奇病毒A16型和肠道病毒71型感染状况调查

doi: 10.16462/j.cnki.zhjbkz.2016.08.004

北京市疾病预防控制中心传染病地方病控制所, 北京 100013

详细信息

作者简介:
李洁(1981-),女,山西运城人,主管技师,在读博士研究生。主要研究方向:传染病预防与控制。

中图分类号: R512.51;R512.57
计量
- 文章访问数: 322
- HTML全文浏览量: 92
- PDF下载量: 35
- 被引次数: 0
出版历程
- 收稿日期: 2016-03-18
- 修回日期: 2016-05-01

Serological survey of coxsackie virus A16 and enterovirus 71 infections among different population groups in Beijing

Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing 100013, China

摘要

摘要: 目的了解北京地区不同人群柯萨奇病毒A16型（coxsachievirus A16,CoxA16）和肠道病毒71型（enterovirus 71,EV71）感染状况。方法 2012年对北京9区进行整群随机抽样，采集血样，开展血清流行病学调查。用酶联免疫吸附实验检测血清中抗CoxA16和抗EV71 免疫球蛋白G（immunoglobulin G,IgG）和免疫球蛋白M（immunoglobulin M,IgM）抗体。结果 2 140名被研究人群中，抗EV71 IgG和IgM阳性率分别为27.0%和1.6%，抗CoxA16 IgG和IgM的阳性率分别为48.5%和4.2%，抗EV71 IgM与抗CoxA16 IgM同时阳性阳性率为0.7%，抗EV71 IgG与抗CoxA16 IgG同时阳性阳性率为17.2%。各年龄组抗EV71 IgM、IgG阳性率、抗CoxA16 IgM、IgG阳性率、抗EV71 IgM 和抗CoxA16 IgM同时阳性的阳性率、抗EV71 IgG和抗CoxA16 IgG同时阳性阳性率差异均有统计学意义（均有P<0.05）。1～岁组抗EV71 IgM阳性率最高，5～岁组抗CoxA16 IgM阳性率最高，10～岁组抗EV71IgG 和20～岁组抗CoxA16 IgG阳性率最高。女性抗CoxA16 IgG阳性率高于男性。结论低龄组儿童是手足口病防控的重点人群，手足口病防控措施制定应考虑地域分布因素。
- 手足口病 /
- 肠道病毒感染 /
- 柯萨奇病毒感染
Abstract: Objective To understand the infection status of coxsackievirus A16 (CoxA16) and enterovirus 71 (EV71) among different population groups in Beijing. Methods A cluster random sampling was performed in nine districts of Beijing in 2012. Blood samples were collected and serological survey was conducted with enzyme-linked immunosorbent assay (ELISA) to detect levels of anti-EV71, anti-CoxA16 immunoglobulin G(IgG)and immunoglobulin M(IgM). Results A total of 2 140 people were enrolled in this study. The seropositive rates of anti-EV71 IgG and IgM were 27.0% and 1.6% respectively. The positive rates were 48.5% and 4.2% for anti-CoxA16 IgG and IgM, respectively. The positive rate of both anti-EV71 and CoxA16 IgM positive was 0.7%. The positive rate of both anti-EV71 and CoxA16 IgG positive was 17.2%. Significant difference of positive rate was observed among different age groups. The age group of 1-4 years old showed the highest positive rate for anti EV71 IgM. The age group of 5-9 years old showed the highest positive rate of anti-Cox16 IgM. The age group of 10-14 years old showed the highest positive rate of anti-EV71 IgG. The age group of 20-24 years old showed the highest positive rate of anti-CoxA16 IgG. The positive rate of anti-CoxA16 IgG was significantly higher in female compared with that in male. Conclusions Young children should be focused by the hand foot and mouth disease (HFMD) prevention and control, and geographical distribution factors should be considered during the development of HFMD prevention and control strategies.
- Hand,foot and mouth disease /
- Enterovirus infections /
- Coxsackievirus infections

HTML全文

参考文献(16)

Zhang Y, Tan XJ, Wang HY, et al. An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China [J]. J Clin Virol, 2009,44(4):262-267.

Zhang Y, Zhu Z, Yang W, et al. An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China [J]. Virol J, 2010,7:94.

钱海坤,贾蕾,李锡太,等. 2009-2012年北京市手足口病空间分布特征研究 [J]. 国际病毒学杂志, 2013,20(5):202-206.

刘芳,李一苇,李晓寒,等. 菏泽市2011年手足口病病原学检测分析 [J]. 国际病毒学杂志, 2012,19(1):24-26.

Zhang Y, Wang J, Guo W, et al. Emergence and transmission pathways of rapidly evolving evolutionary branch C4a strains of human enterovirus 71 in the Central Plain of China [J]. PLoS One, 2011,6(11):e27895.

Huang CC, Liu CC, Chang YC, et al. Neurologic complications in children with enterovirus 71 infection [J]. N Engl J Med, 1999,341(13):936-942.

Zhang Y, Xu WB. Molecular epidemiology of enteroviruses associated with hand, foot, and mouth disease in the mainland of China [J]. Biomed Environ Sci, 2013,26(11):875-876.

王小莉,林长缨,张海艳,等. 北京市入托体检健康儿童肠道病毒71型和柯萨奇病毒A组16型感染状况及就诊行为调查 [J]. 中华流行病学杂志, 2015,36(7):730-733.

贾蕾,李洁,张松建,等. 北京市2010年一起手足口病聚集性死亡疫情分析 [J]. 国际病毒学杂志, 2013,20(6):246-250.

陈艳伟,黎新宇,贾蕾,等. 北京市2012年手足口病重症病例特征聚类分析 [J]. 国际病毒学杂志, 2013,20(5):212-215.

吴晓娜,田祎,王小莉,等. 托幼机构环境和卫生状况与手足口病相关分析 [J]. 国际病毒学杂志, 2013,20(2):60-63.

张东晓,岳丽杰,王冰,等. 深圳市社区人群EV71和CoxA16隐性感染的流行病学分析 [J]. 中国热带医学, 2011,11(11):1332-1333.

周世力,李琳琳,何雅青. 深圳市肠道病毒71型血清流行病学初步调查 [J]. 热带医学杂志, 2007,7(1):66-67.

Ang LW, Phoon MC, Wu Y, et al. The changing seroepidemiology of enterovirus 71 infection among children and adolescents in Singapore [J]. BMC Infect Dis, 2011,11:270.

郭瑞玲,李燕霞,马艳霞,等. 肠道病毒CoxA16 IgG血清流行病学研究 [J]. 中华疾病控制杂志, 2011,15(9):819-821.

Xing W, Liao Q, Viboud C, et al. Hand, foot, and mouth disease in China, 2008-12: an epidemiological study [J]. Lancet Infect Dis, 2014,14(4):308-318.

施引文献

资源附件(0)

访问统计