Abstract: Objective To investigate the situation of the mortality of respiratory system diseases in the disease surveillance points of Guangxi from 2008 to 2012, and to provide scientific evidence for prevention and control of respiratory system diseases.Methods The data of Guangxi were collected from Guangxi disease surveillance points death registration report information system. The statistical data of respiratory system diseases leading to death was analyzed.Results A total of 12 041 respiratory system diseases cases were reported from 2008 to 2012 in the province, with annual mean mortality of 78.95 per 100 thousand and standardized mortality rate of 77.63 per 100 thousand. The chi-square test for trend was statistically significant(χ²=7.59,P=0.006). The mortality rose with the increase of age. The mortality of respiratory system diseases was 86.33 per 100 thousand in male and 70.79 per 100 thousand in female, and the mortality between male and female was not significant different (Z=1.38,P=0.167). The mortality of respiratory system diseases was 27.82 per 100 thousand in urban and 101.91 per 100 thousand in rural. The mortality between urban and rural was significantly different (Z=6.44,P<0.001), and it was higher in rural than in urban. The mortality of chronic obstructive pulmonary disease was 71.58 per 100 thousand, which was the highest mortality of the main respiratory system disease.Conclusions The respiratory disease mortality differen of Guangxi monitoring points increased with age, the disease mortality rate of rural residents was higher than urban residents, and therefore prevention of respiratory disease should focus on older rural residents.