Abstract: Objective To evaluate the effect of follow-up intervention on HIV/AIDS patients. Methods Stratified random sampling method was used to investigate HIV/AIDS patients from the five demonstration city in Henan Province. Baseline and follow-up survey were conducted among participants to analyze the social support and the adherence to highly active antiretroviral therapy (HAART). Results A total of 911 and 860 HIV/AIDS patients were included by the baseline and follow-up survey, among each 798 and 795 participants received HAART. The total social support scores of the baseline and follow-up survey on HIV/AIDS patients were (38.64±7.87) and (40.36±7.45), respectively, and significant differences were found (t=4.486,P<0.001). The total score of social support and its all dimensions in the following-up survey were higher than those of the baseline survey (all P<0.05). The patients adherence to HAART before and after the follow-up intervention, the significant differences were found between better medication compliance and poor medication compliance (χ²=20.648,P<0.001). Conclusions Follow-up intervention could significantly improve the social support and the adherence to HAART, and the higher social support could enhance the medication compliance.