Abstract: Qualitative research is a common method for sociology and anthropology, its core characteristic is highlighted in the humanistic care and respect. It could explore some sensitive problems in a way that is deeper and humanized, could learn some deeper problems, and could obtain the information which quantitative research method could not get. AIDS is a disease that is closely related with social factors and individual behavior, and these social factors and individual behavior are affected by many factors such as ethnic, culture, environment and custom. Therefore, in order to explore this complicated and sensitive issues, to gather the sensitive information that is related with social factors and individual behavior, the qualitative research is increasingly applied in the related research of AIDS. This paper mainly introduces the application and problems of the qualitative research method in AIDS research in our country.