Abstract: Objective To investigate the epidemiological features and clinical characteristics of the new Bunyavirus infection in Chaohu Area. Methods We reviewed and analyzed the hospitalized diagnosed cases with severe fever with thrombocytopenia syndrome virus (SFTSV) in Chaohu hospital of Anhui Medical University, from Apr 2012 to Nov 2015. We used descriptive epidemiology method to analyze the epidemiological features, clinical characteristics and influencing factors for the severity of diagnosed cases with SFTSV. Results 57 cases of SFTS were reported during 2012-2015 and the fatality rate was 19.3%; The trend of SFTSV infection had been increasing in Chaohu year by year. Farmers and the olds were the most patients infected with SFTSV; It was prevalent from April to September, and patients were most easily attacked in May and June; Disturbance of consciousness (OR=14.236,95% CI:1.324-152.091), hematuria (OR=2.583,95% CI:1.114-5.990) and high levels of fasting glucose (OR=34.838,95% CI:2.113-569.427) could forecast the severity of SFTSV infection by univariate logistic regression model. Conclusions When the patients are in the event of disturbance of consciousness, hematuria, and high levels of fasting glucose, it indicates a critical condition and medical staff should pay sufficient attention to such performance.