Abstract: Objective To explore the effect of colorectal cancer screening in community residents through the screening of colorectal cancer in community residents in Jinshan District, and to provide reference for the exploration of colorectal cancer screening strategy. Methods A colorectal cancer screening was conducted among Jinshan District residents. A two-step screening model combined with questionnaire survey and FOBT were used. Those who had screening positive all took colonoscopy, and the results were analyzed. Results A total of 58 215 people completed screening and screening completion rate reached 99.07%. Screening positive rate was 25.44%. Colonoscopy compliance rate was 41.87%. The detection rate of colorectal cancer was 0.45%. The detection rate of total lesion was 35.74%. There were significant differences in detection rates between men and women(χ²=224.337,P<0.001). With the increase of age, the detection rate was rising. The detection rate of all age groups were significant different(χ²=37.788,P<0.001). Conclusions Colorectal cancer screening can detect colorectal cancer, adenoma and other diseases. It has important significance for early detection, early diagnosis and early treatment of colorectal cancer.