抗结核药物不良反应发生率及其影响因素分析

蒋博峰; 马晨晨; 陈阳贵; 巴燕; 刘梦迪; 阿丽叶&#183;艾力; 加依娜&#183;拉兹别克; 向阳

doi:10.16462/j.cnki.zhjbkz.2017.02.013

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抗结核药物不良反应发生率及其影响因素分析

doi: 10.16462/j.cnki.zhjbkz.2017.02.013

1. 新疆医科大学公共卫生学院流行病与卫生统计学教研室, 新疆乌鲁木齐 830011;
2. 乌鲁木齐市第一人民医院儿童保健科, 新疆乌鲁木齐 830011;
3. 乌鲁木齐市疾病预防控制中心结核病防治科, 新疆乌鲁木齐 830026

基金项目:

新疆维吾尔自治区自然科学基金（201442137-20）；新疆维吾尔自治区大学生创新基金（201510760065）

详细信息

作者简介:
蒋博峰(1994-),男,湖南道县人,在读本科生。主要研究方向:传染病流行病学。

中图分类号: R978.3
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- PDF下载量: 34
- 被引次数: 0
出版历程
- 收稿日期: 2016-09-04
- 修回日期: 2016-11-21

Analysis on the incidence of adverse reaction and risk factors caused by anti-tuberculosis drugs

1. Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830011, China;
2. Department of Child Health Care, the First People's Hospital of Urumqi City, Urumqi 830011, China;
3. Department of Tuberculosis Control and Prevention, Urumqi Municipal Center for Disease Control and Prevention, Urumqi 830026, China

摘要

摘要: 目的了解肺结核患者服用抗结核固定剂量复合制剂（fixed-dose combination，FDC）致不良反应的发生情况，并探讨其影响因素，为FDC的安全使用提供政策依据。方法选取新疆乌鲁木齐市某区结核病定点防治医院接受治疗的420例初治肺结核患者，监测其疗程中抗结核药物不良反应（adverse drug reactions，ADRs）发生情况，采用单因素和多因素分析方法，研究其ADRs发生的影响因素。结果总不良反应发生率较高，为62.6%。多因素非条件Logistic回归分析显示患有糖尿病与ADRs的发生有关联，与未患糖尿病患者相比，合并糖尿病患者发生ADRs危险的OR=2.509（95%CI：1.226~5.135）。结论糖尿病患者是服用FDC致发生ADRs的高危人群。对于合并糖尿病的结核患者，治疗期间应加强相关指标检测或采用其他治疗方案。
- 抗结核药 /
- 不良反应 /
- 发生率 /
- 危险因素
Abstract: Objective To understand the incidence of adverse reactions caused by the anti-tuberculosis(anti-TB) fixed-dose combination(FDC), and to explore the relevent influencing factors, and to provide the policy basis for the use of FDC. Methods We monitored the incidence of adverse reactions in treatment of 420 newly diagnosed TB patients from a district of Urumqi Tuberculosis Prevention designated hospital, and explored the relevant factors by univariate and multivariate analysis. Results The overall incidence of adverse reactions was 62.6%. Multivariate Logistic regression analysis showed that diabetes was associated with ADRs. Compared with patients without diabetes, patients with diabetes mellitus had higher risk of ADRs, the OR(95% CI) was 2.509 (1.226-5.135). Conclusions Diabetic patients with FDCs had high risk of ADRs. For these petients, we should detect the relevant indicators closely or use other treatments.
- Anti-TB drugs /
- Adverse reactions /
- Incidence /
- Risk factors