北京某社区不同性别老年人群血尿酸水平与高血压的现况研究

吴蕾; 何耀; 刘淼; 王建华; 王义艳; 曾静; 张迪; 姜斌

doi:10.16462/j.cnki.zhjbkz.2017.03.003

北京某社区不同性别老年人群血尿酸水平与高血压的现况研究

doi: 10.16462/j.cnki.zhjbkz.2017.03.003

吴蕾^1,2,
何耀^1,2,3, ,,
刘淼^1,2,
王建华^1,2,
王义艳^1,2,
曾静^1,2,
张迪^1,2,
姜斌⁴

1. 中国人民解放军总医院老年医学研究所流行病学教研室, 北京 100853;
2. 中国人民解放军总医院衰老与相关疾病研究北京市重点实验室, 北京 100853;
3. 中国人民解放军总医院肾脏疾病国家重点实验室, 北京 100853;
4. 中国人民解放军总医院南楼中医针灸科, 北京 100853

基金项目:

国家自然科学基金（81072355）；国家科技部973项目（2013CB530800）；军事医学创新专项（13CXZ029）

详细信息

作者简介:
吴蕾(1985-),女,北京人,主管技师,硕士。主要研究方向:慢性病流行病学

中图分类号: R544.1;R181.22
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出版历程
- 收稿日期: 2016-09-25
- 修回日期: 2016-12-11

Cross-sectional study on the association between serum uric acid level and hypertension by gender in the elderly population of a district in Beijing

WU Lei^1,2,
HE Yao^{1,2,3
, ,},
LIU Miao^1,2,
WANG Jian-hua^1,2,
WANG Yi-yan^1,2,
ZENG Jing^1,2,
ZHANG Di^1,2,
JIANG Bin⁴

1. Department of Epidemiology, Institute of Geriatrics, People's Liberation Army General Hospital, Beijing 100853, China;
2. Beijing Key Laboratory of Research on Aging and Related Diseases, People's Liberation Army General Hospital, Beijing 100853, China;
3. State Key Laboratory of Kidney Disease, People's Liberation Army General Hospital, Beijing 100853, China;
4. Department of Chinese Traditional Medicine and Acupuncture, People's Liberation Army General Hospital, Beijing 100853, China

摘要

摘要: 目的在社区老年人群中，探讨血尿酸（serum uric acid，SUA）水平与高血压的关系。方法在2009年9月~2010年6月期间，使用整群随机抽样的方法对北京市万寿路地区60岁及以上的老年人进行横断面调查。结果本研究的分析样本为2 074例老年人（男性839例，女性1 235例）。在老年女性的研究对象中，血尿酸水平的增加使高血压的患病风险增加（OR=1.004，95% CI：1.002~1.006，P<0.001）；以血尿酸四分位数最低组作为参照组，随着血尿酸水平增加，高血压的患病风险增加（血尿酸水平Q2（OR=1.263，95% CI：0.902~1.773，P=0.187），血尿酸水平Q3（OR=2.008，95% CI：1.412~2.872，P<0.001）和血尿酸水平Q4（OR=2.015，95% CI：1.403~2.922，P<0.001））；患有高尿酸血症者，罹患高血压的风险高于非高尿酸血症者（OR=1.563，95% CI：1.082~2.253，P=0.018）。在男性中，仅血尿酸水平使高血压的患病风险增加（OR=1.002，95% CI：1.000~1.004，P=0.036）。结论血尿酸水平与高血压有相关性，特别是在老年女性当中。临床医生应特别关注老年女性的血尿酸水平，维持正常的血尿酸水平可能对高血压的预防和控制具有重要作用。
- 高血压 /
- 老年人 /
- 横断面研究 /
- 高尿酸血症
Abstract: Objective To evaluate the association between the serum uric acid (SUA) level and the prevalence of hypertension in community elderly population. Methods A population-based cross-sectional study was conducted in Wanshoulu area of Beijing, China. Results A total of 2 074 community elderly (839 males and 1 235 females) participants aged≥60 years were included in the analysis. In female participants, the adjusted odds ratio (OR) and its corresponding 95% confidence interval of having hypertension was (OR=1.004,95% CI:1.002-1.006, P<0.001) for each 1 μmol/L increase in the SUA level after multiple adjustments. Compared to Q1, the OR adjusted (95% CI) of the Q2 vs. Q1, Q3 vs. Q1 and Q4 vs. Q1 SUA quartiles for hypertension were (OR=1.263,95% CI:0.902-1.773, P=0.187),(OR=2.008,95% CI:1.412-2.872, P<0.001),(OR=2.015,95% CI:1.403-2.922, P<0.001), respectively. The adjusted OR (95% CI) of hyperuricemia for hypertension was (OR=1.563,95% CI:1.082-2.253, P=0.018). In males, the adjusted OR (95% CI) of having hypertension was (OR=1.002,95% CI:1.000-1.004, P=0.036) for each 1 μmol/L increase in the SUA level. Conclusions There is a correlation between SUA level and hypertension, especially in the elderly women. Clinicians should pay special attention to SUA level of elderly women. Maintaining the normal level of SUA may play an important role in hypertension prevention and control.
- Hypertension /
- Elderly people /
- Cross-sectional study /
- Hyperaricemia