Abstract: Objective To investigate and compare the effectiveness of three different management methods for diabetics patients, so as to master the knowledge and skills of their self-management. Methods Totally 213 patients with diabetes in urban community were enrolled in this study in October 2012 and randomly divided into 3 groups: control group (106 cases), strengthening group (75 cases) and comprehensive group (32 cases). During 18 months, different grouping managements were applied to the patients in 3 groups. Then a comparative analysis was performed for Fasting plasma glucose(FPG)， Hemoglobin A1c(HbA1c), relevant knowledge of diabetes and behavior improvement of these patients before and after management. Results The differences of control rates of FPG and HbA1c among 3 groups before grouping management had not statistical significance(all P>0.05). After 18 months of management, both the values of FPG and HbA1c of the patients had declined and the differences among 3 groups showed statistically significance (all P<0.05).The knowledge of diabetes and self-management behavior of the patients have improved after grouping managements and the improvement rates have statistical significant (all P<0.05). Conclusions Management of comprehensive group is more beneficial to control the development of diabetes. This kind of management is more efficient in improvement of control rates of FPG and HbA1c and increasing the mastery rates of the knowledge and skills for patients with diabetes.