Abstract: Objective To explore the trend of coronary heart disease (CHD) mortality and disease burden in Jinchang Cohort. Methods The data were collected from a large follow-up cohort. The main indicators, including mortality, potential years of life lost (PYLL), and working years of potential life lost (WYPLL), were used to evaluate the trend of coronary heart disease mortality and the disease burden during the period from 2001 to 2013 in this cohort, the average growth rate was used to describe the trend of disease burden. Results The crude mortality rate of CHD during the period from 2001 to 2013 in Jinchang cohort was 40.47 per 100 000, the standardized mortality rate of CHD for male increased, but the coronary heart disease mortality of 70-79 years old group decreased. During the thirteen years, the average potential years of life lost (APYLL) of CHD for female (15.33 years per person) was 2.21 times than male (6.95 years per person), the average working years of potential life lost (AWYPLL) of CHD for female (5.59 years per person) was 1.63 times than male (3.42 years per person), while the average working years of potential life lost (AWPYLL) and the average potential life lost (APYLL) for male decreased. Conclusions The mortality rate of CHD on the rise from 2001 to 2013 in Jinchang cohort and it caused heavy burden. We should take further measures to prevent CHD.