陕西省咸阳市健康人群麻疹抗体水平监测及免疫效果流行病学评价

张荣强; 谭姣; 韩莉欣; 刘启玲; 孙娜; 李凤英

doi:10.16462/j.cnki.zhjbkz.2017.03.015

陕西省咸阳市健康人群麻疹抗体水平监测及免疫效果流行病学评价

doi: 10.16462/j.cnki.zhjbkz.2017.03.015

张荣强^1,2,
谭姣³,
韩莉欣²,
刘启玲¹,
孙娜¹,
李凤英^4, ,

1. 陕西中医药大学公共卫生学院流行病与卫生统计学教研室, 陕西咸阳 712046;
2. 西安交通大学医学部, 陕西西安 710049;
3. 西安医学院公共卫生系流行病与卫生统计学教研室, 陕西西安 710021;
4. 咸阳市疾病预防控制中心免疫规划科, 陕西咸阳 712046

基金项目:

陕西中医药大学校内基金（2015QN5）

详细信息

作者简介:
张荣强(1983-),男,山东德州人,讲师,在读博士研究生。主要研究方向:慢性病流行病学

中图分类号: R186.6;R272.22
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- 被引次数: 0
出版历程
- 收稿日期: 2016-10-12
- 修回日期: 2017-01-26

Surveillance of measles antibody levels in healthy people and epidemiological evaluation on the immune effect in Xianyang City, Shaanxi Province

1. Department of Epidemiology and Health Statistics, Public Health School, Shaanxi University of Chinese Medicine, Xianyang 712046, China;
2. Department of Medicine, Xi'an Jiaotong University, Xi'an 710049, China;
3. Department of Epidemiology and Health Statistics, Public Health School, Xi'an Medical University, Xi'an 710021, China;
4. Department on Immunology, Xianyang Center for Disease Control and Prevention, Xianyang 712046, China

摘要

摘要: 目的动态监测咸阳市健康人群麻疹抗体水平，并对麻疹相关疫苗的免疫效果进行流行病学评价。方法 2012-2015年，随机抽取咸阳市1 135例健康人群，采用酶联免疫吸附试验（enzyme-llinked immunosorbent assay，ELISA）检测麻疹抗体光密度（optical density，OD）值；并收集调查对象的免疫史情况，采用Logistic回归对麻疹相关疫苗进行流行病学评价。结果 2012-2015年调查对象的麻疹抗体OD值随年份略有下降趋势，在男女之间差异均无统计学意义（均有P>0.05），OD值在2~3岁最高，随年龄增长有下降趋势；2012-2015年咸阳市健康人群麻疹抗体阳性率分别为：98.91%、96.81%、96.46%、85.11%；经Logistic回归分析，麻疹疫苗和麻腮风疫苗联合使用及麻疹疫苗单独使用对机体均具有明显的保护作用（麻疹疫苗+麻腮风疫苗+：OR=0.123，95% CI：0.046~0.328；麻疹疫苗+麻腮风疫苗-：OR=0.109，95% CI：0.043~0.281）。结论咸阳市健康人群中虽已建立起免疫屏障，但麻疹抗体监测及查漏补种工作仍不能松懈；麻疹疫苗是基础疫苗，对麻疹抗体的形成是必要的，麻腮风疫苗可作为强化疫苗，不能单独使用。
- 麻疹 /
- 麻疹疫苗 /
- 抗体 /
- 免疫, 群体
Abstract: Objective To dynamically monitor measles antibody among healthy people and to conduct an epidemiological evaluation of immune effects of measles related vaccines in Xianyang, 2012-2015. Methods A total of 1 135 healthy people were randomly selected in Xianyang and Enzyme-Llinked Immunosorbent Assay (ELISA) was used to detect OD values of measles antibody. Meanwhile, immunization history was collected to survey their immunization situation. Logistic regression was used to conduct an epidemiologic evaluation of measles related vaccines. Results The OD values of measles antibody decreased but there was no significant difference (all P>0.05) between different genders. The positive rates of measles antibody among healthy subjects in Xianyang from 2012 to 2015 were 98.91%, 96.81%, 96.46% and 85.11%, respectively; Logistic regression analysis showed that measles vaccine had a significant protective effect (measles + MMR vaccine +: OR=0.123, 95% CI: 0.046-0.328; measles vaccine + MMR vaccine-: OR=0.109, 95% CI: 0.043-0.281). Conclusions Although measles immune barrier among healthy people in Xianyang has been established, measles antibody monitoring still need to be strengthened; measles vaccine is the necessary basis for the establishment of measles antibody. MMR vaccine can be used to strengthen the vaccine but it is better not be used alone.
- Measles /
- Measles vaccine /
- Antibodies /
- Immunity, herd