Current situation of drug resistance of 236 mycobacterium tuberculosis from Qinghai
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摘要: 目的 通过对青海地区236株结核分枝杆菌(mycobacterium tuberculosis,M.tb)进行分离培养与耐药性检测,了解青海地区结核病(tuberculosis,TB)的耐药现状,为青海地区结核病防治提供参考依据。方法 对青海地区分离的236株结核分枝杆菌用改良罗氏培养基进行培养,采用比例法进行耐药性检测,分析该地区结核病耐药状况与人口学特征的关系,并对结果进行统计分析。结果 236株结核分枝杆菌总耐药率为55.93%(132/236);四种一线药物耐药率由高到低依次是异烟肼(isoniazid,INH)为43.22%,链霉素(streptomycin,SM)为38.14%,利福平(rifampin,RFP)为37.29%,乙胺丁醇(ethambutol,EMB)为28.81%;单耐药结核病(single drug resistance tuberculosis,SDR-TB)比例为12.71%;耐多药结核病(multidrug resistant tuberculosis,MDR-TB)和广泛耐药结核病(extensivelydrug resistant tuberculosis,XDR-TB)所占比例分别是30.93%(73/236)和1.27%(3/236);青海地区的结核分枝杆菌耐药状况与地区和年龄有关(均有P<0.05),与性别和民族无关(均有P>0.05)。结论 青海地区耐药结核病比率高于全国水平,要加强该地区结核病的预防控制,对结核病患者进行规范化治疗。Abstract: Objective Through 236 strains of mycobacterium tuberculosis(M.tb) insolation and cultivation to explore drug resistance situation of mycobacterium tuberculosis which circulating in Qinghai area, so as to provide reference for TB prevention and control in this area. Methods A total of 236 strains of mycobacterium tuberculosis isolated in Qinghai were cultured with L-J medium.Drug resistance was tested by using the proportional method.The relationship between TB drug resistance and the demographic characteristics were analyzed. Results The results showed that drug resistance rate of 236 mycobacterium tuberculosis was 55.93% (132/236). Resistance rates of four first-line drugs from high to low were 43.22% for isoniazid, 38.14%for streptomycin, 37.29% for rifampin and 28.81% for ethambutol. MDR-TB and XDR-TB were 30.93% (73/236) and 1.27% (3/236) respectively. The ratio of SDR-TB was 12.71%. This drug-resistance TB were associated with regions and ages (all P<0.05), but were not associated with gender and ethnicity (all P>0.05). Conclusions The drug-resistance TB of Qinghai is higher than the national level.Measures of prevention and standardized treatment of tuberculosis patients should be strengthened in this area.
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Key words:
- Mycobacterium tuberculosis /
- Drug resistance /
- Qinghai
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