Abstract: Objective To compare the clinicopathological characteristics between familial breast cancer and sporadic breast cancer, and to reveal the unique clinical pathology and molecular biological characteristics of familial breast cancer. Methods The clinical and pathological data of 445 patients with breast cancer from January 2013 to January 2014 in Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital of Guangxi Medical University were analyzed retrospectively, 43 of them were familial breast cancer and 402 were sporadic. The clinical pathological features, molecular biological behaviors, recurrence and metastasis of the two groups were compared and analyzed. Results The proportion of patients with familial breast cancer at histological grade Ⅲ (37.2%) was significantly higher than the sporadic breast cancer (22.6%), the difference was statistically significant(χ²=4.517,P=0.034).The negative rate of ER expression in familial breast cancer patients (39.5%) was higher than that in sporadic breast cancer patients (25.4%),the difference was statistically significant(χ²=3.977,P=0.046).Kaplan-Meier survival analysis showed that:3-year disease-free survival rate (DFS) was 86.0% in the familial breast cancer and the rate in the sporadic group was 95.5%, the difference was statistically significant (χ²=7.371, P=0.007).But in the two groups, the age distribution, nationality, BMI, menopausal status, tumor size, pathological type, clinical stage, axillary lymph node metastasis rate,PR,HER-2,Ki-67 and breast cancer molecular subtypes were not statistically significant. Conclusions There are some differences in clinicopathological characteristics between the familial breast cancer and sporadic breast cancer in Guangxi province, and familial breast cancer may indicate worse prognosis.