单纯疱疹病毒2型感染与缺血性脑卒中不良预后的关系

张培培; 黄萍; 国钰梅; 吕利英; 周蓦; 龙振海; 张永红; 许锬

doi:10.16462/j.cnki.zhjbkz.2017.06.009

单纯疱疹病毒2型感染与缺血性脑卒中不良预后的关系

doi: 10.16462/j.cnki.zhjbkz.2017.06.009

张培培¹,
黄萍²,
国钰梅³,
吕利英³,
周蓦⁴,
龙振海⁵,
张永红¹,
许锬^1, ,

1. 苏州大学医学部公共卫生学院流行病与卫生统计学系, 江苏苏州 215123;
2. 常州市武进区湖塘镇鸣凰社区卫生服务中心防保科, 江苏常州 213164;
3. 内蒙古兴安盟人民医院检验科, 内蒙古兴安盟 137400;
4. 苏州市立医院科教科, 江苏苏州 215123;
5. 辽宁省阜新市中心医院神经科, 辽宁阜新 123000

基金项目:

国家自然科学基金（81172760）

详细信息

作者简介:
张培培(1990-),女,江苏宿迁人,在读硕士研究生。主要研究方向:流行病与卫生统计学。

中图分类号: R512.92;R181
计量
- 文章访问数: 271
- HTML全文浏览量: 60
- PDF下载量: 36
- 被引次数: 0
出版历程
- 收稿日期: 2017-01-29
- 修回日期: 2017-03-31

Herpes simplex virus 2 infection is associated with adverse prognosis for ischemic stroke

1. Department of Epidemiology and Health statistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China;
2. Department of Prevention and Health, Minghuang Community Health Service Center, Hutang Town, Wujin District, Changzhou 213164, China;
3. Clinical Laboratory, People's Hospital of Xing'an meng, Xing'an meng 137400, China;
4. Department of Science and Education, Suzhou Municipal Hospital, Suzhou 215123, China;
5. Department of Neurology, Fuxin Central Hospital, Fuxin 123000, China

摘要

摘要: 目的探讨单纯疱疹病毒2型（herpes simplex virus 2，HSV-2）感染与缺血性脑卒中发病后14 d（或出院）时不良预后的关系。方法 2011年6月~2013年12月，本研究采用队列研究的方法，从国内14家医院纳入确诊的缺血性脑卒中病例1 150例，检测入院时血清HSV-2 IgG水平，以发病后14 d（或出院）发生死亡或心血管事件为不良预后，采用Logistic回归方法分析HSV-2 IgG水平与不良预后的关系。结果依HSV-2 IgG四分位数将病例分为4组，以第1分位组为参照组，经多因素调整后第4分位组发生不良预后的风险是参照组的4.32倍（95% CI：1.33~14.03，P=0.015），且随不同组间HSV-2 IgG水平的增加，不良预后的发生风险有增加的趋势。亚组分析发现，病例为女性、或不饮酒、或伴有糖尿病、或伴有高血压时，高水平HSV-2 IgG可增加14 d（或出院）时不良预后的发生风险（均有P<0.05）。结论缺血性脑卒中伴HSV-2感染时，高水平的HSV-2 IgG能增加病后14 d（或出院）时不良预后的发生风险，且随HSV-2 IgG水平的增加，不良预后的发生风险有增加的趋势。
- 疱疹病毒2型，人 /
- 卒中 /
- 流行病学研究
Abstract: Objective To examine the association between herpes simplex virus type 2 (HSV-2) infection and the adverse prognosis at 14 days (or discharge) after onset of ischemic stroke. Methods A cohort study of 1150 ischemic stroke cases was conducted, who were from 14 hospitals with confirmed diagnosis and blood HSV-2 IgG tested. Adverse prognosis was defined with death or onset of cardiovascular events after 14 days (or discharge). Logistic regression was applied to estimate the association between HSV-2 and adverse prognosis. Results HSV-2 IgG was classified with quartile. First quartile was used with reference, after multiple factors adjusted, fourth quartile was 4.32-fold risk to first quartile (P=0.015), the risk was increased with the level elevated in quartile groups.Subgroup analysis showed that elevated HSV-2 IgG increased the risk of adverse prognosis among cases in female, or non-drinking, or with diabetes, or with hypertension (all P<0.05). Conclusions In ischemic stroke with HSV-2 infection, elevated HSV-2 IgG may increase the risk of adverse prognosis at 14 days (or discharge)after onset of ischemic stroke, the risk may increase with the HSV-2 IgG level elevated.
- Herpesvirus 2, human /
- Stroke /
- Epidemiologic study