Abstract: Objective To investigate influencing factors for measles infection in persons aged ≤7 month,8 month-14 year and ≥15 year, so as to provide a scientific basis for measles intervention strategies. Methods Laboratory confirmed measles cases from China information system of disease prevention were selected, the study was conducted using the method of group comparison investigation. Results 232 cases and controls were respectively recruited into the study in all three age groups. Multi-factor analysis showed that, risk factors for measles infection in infants aged ≤7 month were aged 6-7 month (OR=5.255,95% CI:3.092-8.931), living in urban-rural fringe area (OR=3.035,95% CI:1.236-7.454), preterm birth (OR=14.896,95% CI:3.756-59.074), protective factors were breast feeding (OR =0.297,95% CI:0.153-0.574) and have brothers and sisters (OR =0.464,95% CI:0.276-0.781). Risk factors for measles infection in children aged 8 month - 14 years were living in urban-rural fringe area(OR=3.347,95% CI:1.365-8.204), premature birth(OR=3.171,95% CI:1.185-8.487), protective factors were breast-feeding (OR=0.313,95% CI:0.175-0.558). Risk factors for measles infection in children aged ≥ 15 year were the floating population (OR =3.900,95% CI:1.633-9.311), living in urban-rural fringe area (OR=5.564,95%CI:2.485-12.459), protective factors was living with children aged < 15 years (OR= 0.383,95% CI: 0.216-0.682).We also found other factors, such as male, grandparents care, going out and hospital visits were risk factors, and having vaccination certificates, measles containing vaccine(MCV) immunization were protective factors. Conclusions According to the results of this study, we propose to ensure two doses of 95% vaccination rate of MCV and timely vaccination of the first dose, to reduce the occurrence of nosocomial infections, to advocate eugenics, breast feeding and try to avoid going to crowded places in high incidence seasons of measles.