Abstract: Objective To analyze the epidemiological characteristics and genotypes of measles in Hubei province during 2012-2015, so as to provide evidence for measles control. Methods Data were collected through surveillance system of infectious disease and measles. Descriptive epidemiological analysis was conducted on measles surveillance data in Hubei.The nucleoprotein (N) genes of measles virus were amplified by one-step RT-PCR and sequenced for phylogenetic analysis. Results A total of 3 258 measles cases were reported and the average annual incidence was 14.063/1 000 000 with significant increases in 2014 and 2015. The peaks of incidence of measles were different each year from 2012-2015. Measles virus outbreak levels in 2014 and 2015 were higher than those in 2012 and 2013. The measles cases were mainly in children under 2 years old and young adults aged 15 years and above. Scattered children, farmers and household service had higher incidence of measles.Most genotypes of measles virus in Hubei belonged to H1 and H1a subgenotype during 2012-2015, only one strain was subgenotype D8 in 2013. Conclusions The incidence of measles increased during 2012-2015. The main genotype of measles virus was H1a, only 1 case of D8 subtype was found. It was important to enhance measles surveillance and promote vaccination program in children and immigrant workers to protect the whole population.