Investigation of the correlative factors for osteoporosis among elderly male patients with type 2 diabetes
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摘要: 目的 探讨与老年男性2型糖尿病(type 2 diabetes mellitus,T2DM)骨质疏松(osteoporosis,OP)发生相关的因素。方法 选取老年男性T2DM患者288例,根据OP诊断标准分为骨量正常组(72例)、骨量减少组(118例)和骨质疏松组(98例)。测量身高、体重,计算体质指数(body mass index,BMI);测定空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白(glycosylated hemoglobinA1c,HbA1c)、甲状旁腺素(parathyroid hormone,PTH)、血清钙(serum calcium,Ca)、血清磷(serum phosphonium,P)、25羟维生素D (serum 25-hydroxyvitamin D,25-OH-VD)及尿白蛋白/肌酐(urinary albumin/creatinine ratio,ACR),记录患者病程、降糖药物使用和糖尿病慢性并发症情况。结果 与骨量正常组比较,骨质疏松组和骨量减少组病程较长和HbA1c较高,BMI减低,差异均有统计学意义(均有P<0.05)。相关分析显示股骨颈、三角区、大转子、腰椎(lumbar vertebrae,L)2-4节骨密度(bone mineral density,BMD)与BMI均呈正相关(均有P<0.05),但与HbA1C均呈负相关(均有P<0.05)。骨质疏松组糖尿病肾病、糖尿病视网膜病变发生率均高于骨量正常组、骨量减少组(均有P<0.05);骨质疏松组糖尿病神经病变发生率高于骨量正常组(χ2=6.168,P=0.013)。Logistic回归分析显示BMI、HbA1c及糖尿病肾病与糖尿病骨质疏松发生相关(均有P<0.05)。结论 低BMI,血糖控制不佳和糖尿病肾病是老年男性T2DM患者OP发生的危险因素。Abstract: Objective To explore the related factors for osteoporosis(OP) among elderly male patients with type 2 diabetes(T2DM). Methods A total of 288 elderly male patients with T2DM were divided into 3 groups according to the diagnosis standards of OP:normal group(n=72), ostepenia group(n=118)and osteoporosis group(n=98). Body height, weight were measured and body mass index(BMI) was calculated.Fasting blood glucose(FBG), glycosylated hemoglobinA1c (HbA1c), parathyroid hormone(PTH), serum calcium(Ca), serum phosphonium(P), serum 25-hydroxyvitamin D(25-OH-VD) and urinary albumin/creatinine ratio(ACR) were detected. Diabetic course, diabetes specific therapy and diabetic chronic complications were recorded. Results Compared with normal group, ostepenia and osteoporosis groups had longer diabetic course, higher HbA1c levels, and lower BMI (all P<0.05). Correlation analysis showed that bone mineral density(BMD) value of femoral neck, Ward's triangle region, greater trochanter and lumbar spine L2-4 were positively correlated with BMI(all P<0.05), but negatively correlated with HbA1c(all P<0.05). The incidences of diabetic nephropathy, diabetic retinopathy were higher in osteoporosis group than in normal and ostepenia groups (all P<0.05),and the incidence of diabetic neuropathy was higher in osteoporosis group than in normal group (χ2=6.168, P=0.013). Logistic regression analysis showed that BMI, HbA1c and diabetic nephropathy were correlated with diabetetic osteoporosis(all P<0.05). Conclusions Low BMI, poor blood glucose control and diabetic nephropathy were the risk factors for OP in elderly male patients with T2DM.
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Key words:
- Diabetes mellitus, type 2 /
- Osteoporosis /
- Risk factors
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