Abstract: Epidemiology is a very important method in etiologic research, and the etiologic research is one of the main field of epidemiologic research. Etiologic research become more and more complicated, which promote the rapidly progress of epidemiologic method. We outlined this progress in concept and model of etiology, confounding control, interaction analysis, combination between epidemiology and omics, concept and development of molecular pathological epidemiology, and the criteria of disease cause.