The value of neutrophil-to-lymphocyte ratio as prognosis factor in small cell lung cancer
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摘要: 目的 探讨治疗前外周血中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio，NLR）与小细胞肺癌患者预后的关系。方法 回顾性分析2013年1月~2015年3月安徽医科大学第一附属医院病理诊断明确的50例小细胞肺癌患者，所有患者未行手术治疗，以NLR中位数将患者分为高NLR组和低NLR组，对可能影响患者预后的各项因素进行分析。结果 47例病人获得随访。47例患者中1年生存率为53.2%。其中低NLR组的病人1年生存率为83.3%；高NLR组病人1年生存率为21.7%，单因素分析显示小细胞肺癌患者的预后与患者的分期、体力状况ECOG评分以及NLR水平相关（均有P<0.05），对与预后相关的变量进行COX多因素分析，结果显示分期处于广泛期和高NLR水平是影响患者预后的独立危险因素（均有P<0.05）。结论 NLR可能是小细胞肺癌患者预后的独立危险因素。Abstract: Objective To assess the association of neutrophil-to-lymphocyte ratio (NLR) with the prognosis of small-cell lung cancer in patients who received the standard treatment. Method A total of 50 cases of small-cell lung cancer pathologically diagnosed without surgery at the first affiliated hospital of Anhui medical university between January 2013 and March 2015 were included in this study. All patients were classified into two groups based on the median value of NLR. Various factors that might influence the prognosis of patients were analyzed. Results A total of 47 patients were followed up. The 1-year survival rate was 53.2%. In the low NLR group, 1-year survival rate was 83.3%. In the high NLR group, 1-year survival rate was 21.7%. Univariate analysis showed that clinical stage, ECOG, and the level of NLR were associated with survival (all P<0.05). Multivariate analysis identified clinical stage and NLR as independent prognostic factors of patients (all P<0.05). Conclusion NLR may be an independent prognostic factor of small-cell lung cancer patients.
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Key words:
- Carcinoma, small cell /
- Lymphocytes /
- Prognosis
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