Abstract: Objective Hepatitis C virus patients are often accompanied by insulin resistance and diabetes. To probe the relative factors of abnormal glycometabolism in chronic HCV infections. Methods A total of 1 039 treatment-naive patients that were confirmed chronic HCV infected were enrolled in the study. The demographics, biochemical index parameters and other data about liver function and HCV viral load were got from infectious disease department of Jurong Pepole's Hospital in China. Results A total of 140 (13.5%) patients were diagnosed with some forms of abnormal glycometabolism. The body mass index (BMI) (χ²=9.231, P=0.010), waist circumference (χ²=7.984, P=0.018), systolic blood pressure (χ²=16.366, P<0.001), diastolic blood pressure (χ²=13.970, P=0.001), alanine aminotransferase(ALT)(χ²=4.809, P=0.028), HCV-RNA viral load (t=-3.818, P<0.001) were significantly different between non-diabetic HCV patients and abnormal glycometabolism patients. Multivariate logistic regression analysis showed that ALT(OR=2.986, 95% CI:1.171-7.615) and HCV-RNA viral load (OR=2.061, 95% CI:1.165-3.644) were found as risk factors in multivariate regression analysis for patients with chronic hepatitis C who had abnormal glucose metabolism. Conclusions Chronic hepatitis C patients with higher ALT and HCV-RNA level were more probably to suffer from abnormal glycometabolism. In order to find potentially novel risk factors of HCV with abnormal glucose metabolisn, further studies about genetic and other clinical factors need to be processed.