Abstract: This editorial introduced the definition of biomarkers and exposome, as well as their implication in environmental health studies. Four topics were introduced that include biomarkers and exposome, lifestage exposome snapshots, exposome wide association studies, and the role of biomarkers in studying the relationship between environmental exposures and diseases. Emphases of studies were suggested that include validity assessment of biomarkers, organ specificity of biomarkers, and bioinformatics for analyzing multi-level omics data.