Abstract: Objective To investigate the current situation of life satisfaction among medical students, and to explore its association with resilience or coping style. Methods Life satisfaction, resilience, and coping styles of 1 300 medical students were evaluated with the multidimensional student's life satisfaction scale, Connor-Davidson resilience scale and trait coping style questionnaire. t-test or ANOVA was conducted to compare the scores of different groups. The correlation of variables was analyzed with Pearson correlation analysis. Results The average score of life satisfaction among medical students was (4.38±0.61). Univariate analysis showed that gender, paternal and maternal educational levels were determinants for life satisfaction. Correlation analysis showed that life satisfaction was positively associated with resilience and positive coping, but was negatively associated with negative coping. After adjusting gender and/or paternal education, it was shown that resilience and positive coping were independent factors for overall and each dimensional life satisfaction. Meanwhile, negative coping was an independent factor for all life satisfactions except family satisfaction. Conclusions Resilience and coping style are associated with life satisfaction among medical students.