Abstract: Objective To estimate the excess mortality caused by influenza in Shenzhen from 2013 to 2015, in order to provide scientific reference for understanding the epidemic characteristics of influenza and formulating the strategy of vaccination. Methods All reported influenza deaths in Shenzhen from 2013 to 2015 were collected and divided into three groups, including all-age, < 65years old and ≥ 65 years old groups. Based on the data of all cause deaths (AC),respiratory and circulatory deaths (R&C) and pneumonia and influenza deaths (P&I), age-specific Serfling cyclical regression model was established to estimate the influenza-associated excess mortality and death numbers for three groups. Results From 2013 to 2015, the AC-based estimates of the annually averaged excess death and mortality due to influenza were 652.80 and 6.11 per 100 000 person years respectively. The R&C-based estimates excess death and mortality due to influenza were 449.78 and 4.21 per 100 000 person years respectively. The P&I-based estimates excess death and mortality due to influenza were 44.94 and 0.42 per 100 000 person years respectively. Conclusions Serfling cyclical regression model shows that the elderly, especially those already suffer from respiratory and circulatory system diseases are the high-risk groups of excess death due to influenza.