Abstract: Objective To investigate the prevalence and predictors of depression among patients with diabetes mellitus in Wulumuqi, China. Methods A cross-sectional survey was conducted among patients diagnosed with diabetes in outpatient clinics and inpatients from December 1st, 2016 to April 30th, 2017 in Xinjiang Medical University the Fifth Affiliated Hospital. The depression status was screened using Zung's Self-Rating Depression Scale. Logistic regression model was used to analyze the predictors of depression among diabetic patients. Results The prevalence of depression was 20.00% in 500 patients with diabetes mellitus. The results of logistic regression analysis showed that female (compared to male, OR=2.18, 95% CI:1.49-3.19) and Uyghur (compared to Han ethnic group, OR=2.56,95% CI:1.17-5.57) divorced or widowed (compared to being married, OR=1.74,95% CI:1.04-3.07) were independent risk factors of depression. Education level equal to or higher than college (compared to primary school and lower, OR=0.38, 95% CI:0.19-0.76), family support(Yes/No, OR=0.50,95% CI:0.28-0.91) were protective factors for depression. Conclusions The prevalence of depression in patients with diabetes in Urumqi city is high, and it is related to multiple factors. Early diagnosis and intervention on depression in diabetic patients are recommended to improve the quality of life of diabetic patients.