Abstract: Objective To investigate anxiety/depression in patients with gastric cancer and their relationship with meaning of life (MOL). Methods We enrolled 165 inpatients (aged 25-83 years) with gastric cancer in the department of oncology from two tertiary hospitals. At the same time, we enrolled 165 patients diagnosed as superficial gastritis in outpatient department. We assessed the patients using the resilience scale, meaning in life questionnaire, hospital anxiety and depression scale, and the general data questionnaire. Results The anxiety/depression levels of gastric cancer patients were higher, and the life meaning was lower; MOL was negatively correlated with anxiety/depression in patients with gastric cancer (r=-0.291,P<0.001). MOL played a mediating role between resilience and anxiety/depression in gastric cancer patients. Conclusions The reconstruction of MOL can enhance the resilience of patients and predict the anxiety/depression of patients with gastric cancer.This may provide new insights into clinical research and interventions for anxiety/depression in patients with gastric cancer.