Abstract: In recent years,coxsackievirus A6 (CoxA6) has outbreaken in many countries and some areas of China. It has gradually emerged as a major pathogen of hand-foot-mouth disease (HFMD), causing widespread concern around the world. CoxA6 not only infects children under 5 years of age, but also can cause serious harm to adults. Detoxification is a common clinical manifestation of HFMD caused by CoxA6. In severe cases, neurological symptoms, aseptic meningitis and encephalitis occur. In addition, CoxA6 infection can cause more severe skin lesions. However, the current researches on CoxA6 are not comprehensive, especially about the pathogenesis and animal models of CoxA6. Therefore, summarizing the related researches of CoxA6 will lay the foundation for the future preventions and treatments of CoxA6-induced HFMD, and it can also provide a new idea for the development of CoxA6 vaccine. This review aims to provide an overview of the current prevalence of CoxA6, CoxA6 virus infection, the clinical symptoms, as well as the researches of CoxA6 vaccine.