Abstract: In 19th century, William Augustus Guy, a British doctor, was an outstanding contributor to the history of public health. He devoted his whole life to medical and human causes, which brought profound influence to later generations. One of Guy's most influential works was the first epidemiological case-control study, which was ground breaking in the history of epidemiology. Moreover, Guy also made special contributions in promoting vaccination, improving occupational health, practicing medical hilanthropy, and improving tabular analysis. As a famous physician, he is remembered and respected by future generations for making great break through in statistics and epidemiology.