Abstract: Objective To understand the tuberculosis(TB) spatial distribution characteristics and trends of Qinghai Province and to explore the distribution of hot type and the onset of aggregation, so as to provide evidence for the prevention and control of tuberculosis in Qinghai Province. Methods Data of tuberculosis from 2011 to 2015 in Qinghai were collected and spatial correlation analysis, high/low clustering analysis, hotspot analysis and Kriging interpolation prediction were conducted by spatial epidemiological techniques. Results The results based on five-year average morbidity showed that geographical areas with high incidence of TB in Qinghai were counties of Qumalai, Maduo, Zaduo, Jiuzhi. Low incidence areas were Golmu City, Wulan County, Ping'an, Huangzhong and Huzhu. Trend figures showed that high incidences of TB in Qinghai existed in both east-west direction and the north-south direction, which were consistent with the geographical distribution. Spatial autocorrelation analysis showed that:Moran's I index was 0.32, Z=7.22, P=0.001; High/Low clustering analysis showed that the Getis Gi coefficient was -0.13, Z=-2.00, P=0.045; hot spot analysis showed that most hot spots of TB in Qinghai were concentrated in counties of Zaduo, Qumalai, Chengduo, Dari, Maqing and Banma. Conclusions The geographical distribution of TB in period of 2011 to 2015 in Qinghai was uneven and appeared a positive spatial autocorrelation and displayed a low-low model and a hot spot.