2型糖尿病患者胱抑素C水平与冠脉病变发生风险的关联研究

程诚; 许邦龙; 高峰; 林先和; 刘荣玉

doi:10.16462/j.cnki.zhjbkz.2018.05.016

2型糖尿病患者胱抑素C水平与冠脉病变发生风险的关联研究

doi: 10.16462/j.cnki.zhjbkz.2018.05.016

程诚¹,
许邦龙¹,
高峰¹,
林先和^2, ,,
刘荣玉^3, ,

1. 安徽医科大学第二附属医院心血管内科, 安徽合肥 230601;
2. 安徽医科大学第一附属医院心血管内科, 安徽合肥 230032;
3. 安徽医科大学第一附属医院老年呼吸内科, 安徽合肥 230032

基金项目:

安徽省科技攻关基金（1501041146）

详细信息

作者简介:
程诚(1985-),女,安徽黄山人,主治医师,在读博士研究生。主要研究方向:高血压病的防治。

中图分类号: R541.4;R587.1
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出版历程
- 收稿日期: 2018-01-07
- 修回日期: 2018-03-19

Evaluation of the role of cystatin C in predicting coronary lesions and their severity in type 2 diabetic patients

1. Department of Cardiology, Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China;
2. Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China;
3. Department of Geriatric Respiratoty, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China

摘要

摘要: 目的评价胱抑素C与2型糖尿病患者中冠心病病情及冠脉病变严重程度的相关性。方法随机选取199名怀疑或确诊为冠心病的2型糖尿病患者进行冠脉造影术，依据入院时的病情分组为对照组、稳定性心绞痛、不稳定性心绞痛及急性心肌梗死组；并依据Gensini评分分组为正常冠脉结构组、轻度、中度及重度冠脉病变组，分析评价2型糖尿病患者中胱抑素C和冠心病的关系。结果急性心肌梗死组及重度冠脉病变组的胱抑素C水平升高，且和病情严重程度（r=0.172，P=0.002）及Gensini评分（r=0.177，P=0.002）呈正相关，但在多元回归分析中，不同于糖基化血红蛋白，胱抑素C并不是冠心病合并2型糖尿病患者的病情或冠脉病变严重程度的独立危险因素（均有P>0.05）。结论胱抑素C对于冠心病合并2型糖尿病患者的预测价值不如糖基化血红蛋白，但该指标和冠心病密切相关。
- 胱抑素C /
- 冠心病 /
- 动脉粥样硬化 /
- 糖尿病,2型
Abstract: Objective To evaluate the role of cystatin C in predicting coronary artery disease (CAD) and their severity in type 2 diabetes mellitus (T2DM) patients.Methods Totally 199 T2DM patients who suspected of CAD were enrolled, and underwent coronary angiography. The condition of inpatients (non-CAD, stable angina pectoris (SAP), and unstable angina pectoris (UAP)), acute myocardial infarction (AMI) and Gensini scores were measured to evaluate the severity of CAD and coronary lesions, respectively. Multivariate analysis was performed to evaluate the prediction value of cystatin C as a biomarker.Results Cystatin C levels were significantly elevated in the AMI group, as with in the Gensini score >50 group. Levels were positively correlated with the severity of CAD (r=0.172, P=0.002) and Gensini score (r=0.177, P=0.002). However, contrast to glycosylated hemoglobin,using multivariate analysis, cystatin C was not an independent predictor of CAD severity and vascular lesions in patients with T2DM (all P>0.05).Conclusion Cystatin C is a less sensitive predictor of CAD than HbA1c. However, it appears to correlate with CAD in T2DM patients.
- Cystatin C /
- Coronary disease /
- Atherosclerosis /
- Diabetes mellitus,type 2