Abstract: Objective To investigate the epidemiological characteristics of pesticide poisoning cases in Wuhan, and to provide strategies for the prevention and control of pesticide poisoning.Methods The data of pesticide poisoning in Wuhan from 2006 to 2016 were collected and analyzed by Prism6 software.Results There were total 5 156 pesticide poisoning cases from 2006 to 2016 in Wuhan, occupational poisoning accounted for 39.43% and non-occupational poisoning accounted for 60.57%. Insecticide was the main type, accounting for 65.83%, and most of the insecticide was organophosphorus insecticide (71.57%). The incidence rate of occupational poisoning decreased and a flat trend in the incidence rate was observed in the last three years. By contrast, a trend with small amplitude fluctuation was observed in the incidence rate of non-occupational poisoning. Of total cases, men accounted for 49.40%, while female accounted for 50.60%, the difference was statistically significant (χ²=4.709,P<0.001). The total cases most commonly occurred in the age group of 40-years old (24.26%). Pesticide poisoning peaked at July and August (33.86%). The total cases were mainly found in far districts from the city,accounted for 86.87%.Conclusions Pesticide poisonings mainly occur in suburban areas. Insecticide poisoning is the most common pesticide poisoning. The non-occupational poisoning threat to the safety of people, especially to the middle-aged women, effective measures for the prevention and treatment of pesticide poisoning should be taken as soon as possible.